An associated vaccine against infectious keratoconjunctivitis in cattle based on the antigens of the bacteria Moraxella bovis and Moraxella bovoculi is presented. As antigens, the vaccine con-tains formalin-inactivated cell suspensions of bacterial strains Moraxella bovis «G97-VNIVI» and Moraxella bovoculi «SH-CH6-DEP» taken in the same proportions and the adsorbent is 6 % alumi-num hydroxide gel. The results of studying the immunobiological properties of an associated vaccine against cat-tle ICC based on antigens of bacteria Moraxella bovis and Moraxella bovoculi are presented. The data obtained show that the associated vaccine remained sterile, harmless and antigenically active during the observation period.

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The paper presents the results of studying the efficacy of an associated emulsion vaccine against parainfluenza-3, infectious rhinotracheitis, viral diarrhea, rota- and coronavirus infections in cattle in a production environment. In the manufacture of the associated vaccine, biologically active substances were used in the form of inactivated, purified and concentrated antigens of the following virus strains: "ПТК-45/86" parainfluenza virus-3, "ТК-А (ВИЭВ)-В2" virus of infectious rhinotracheitis, "ВК-1" virus of viral diarrhea-diseases of the mucous membranes of cattle, "РМ" rotavirus and 2 "КЛ-2" coronavirus of cattle obtained in transplanted cell cultures. 8 batches of the associated vaccine were produced. A clinical trial of the effectiveness of the vaccine was carried out in 3 cattle farms of the Republic of Tatarstan, unfavorable for respiratory and intestinal infections of young cattle in terms of morbidity and safety of calves obtained from vaccinated and unvaccinated cows, as well as by titers of specific antibodies in blood serum and colostrum.