The article presents the main results of more than forty-year studies of the hydrogeodeformation field. We have establish some new properties of lithospheric massifs, which are clearly detectable during the periods of fast geodynamic activation (FGeDA). These processes are contrastingly manifested within the planetary megastructure – the Global Endodrainage System (GEDS) of the Earth. The article discusses ideas about the conditions of formation, the specific features of functioning and the role of the asthenosphere as an essential element of the GEDS. It shows the dominant role of fluid processes that take place in the GEDS and provide the conditions for the ‘maturation’ of geodynamic catastrophes. The features of the formation of deformation disturbances and the dominant directions of the planetary migration of deformation impulses from the places of future catastrophic seismic events along the GEDS are considered. The regional hydrogeodeformation monitoring (HDGM) results give evidence of a close relationship between the lithospheric massifs in distant regions of the Earth: replica signals along the GDES length repeat an initial impulse originating from the area of a future seismic event. Attention is given to trigger effects that cause a seismic energy discharge at a large distance and, in some cases, can cause a cascade of earthquakes. It is proposed to create a HDGM system for monitoring of large seismic regions of the Earth.