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Lipolysis is accomplished sequentially and simultaneously by lipase in saliva and gastric juice in the infant’s stomach as inductors in autolytic digestion by bile-dependent lipase in breast milk and colipase-dependent pancreatic lipase in the ileum. Lipase was determined in blood serum of women in labor, in umbilical cord blood, in water, and in infant gastric content. According to the data obtained, the initial lipolysis potential of newborns is significantly lower than that of the mothers. It is developed during the first half of pregnancy so gestation period does not have a significant effect on it. Over a year of lactation period, the breast milk steatolytic activity decreases, with a lower rate compared with other breast hydrolytic activities. If the steatolytic activity is low during the first month of lactation, it increases during the succeeding 4–5 months. In cases when steatolytic activity is high initially, it decreased during the following months. This indicates that the lipase content level has an effect on lipolysis at lactotrophy. Additional food and specifically bottle feeding strongly increased the steatolytic activity of duodenal content because of lipase exosecretion stimulation in the pancreas. In contrast, the steatolytic activity is decreased when mixed feeding is introduced. Assessment of lipolysis potential is important in choosing the feeding type for newborns and infants.

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Коротько Геннадий Феодосьевич, доктор биологических наук, профессор, заслуженный деятель науки УзССР и Кубани, лауреат Премии Правительства Российской Федерации, действительный член (академик) и член-корреспондент нескольких общественных академий РФ, член правления Российского общества хирургов-гастроэнтерологов и член Американской ассоциации хирургов-гастроэнтерологов, научный консультант ГБУЗ «Краевая клиническая больница № 2» министерства здравоохранения Краснодарского края