In order to review the current status of the potential relationship between anesthesia and Alzheimer's disease, a group of scientists recently met in Philadelphia for a full day of presentations and discussions. This special article represents a consensus view on the possible link between Alzheimer's disease and anesthesia and the steps required to test this more definitively.There is growing interest in the potential relationship between anesthesia and the onset and progression of neurodegenerative disorders, including Alzheimer's disease. In an initial attempt to address and coordinate the available evidence and hypotheses, a small group of physicians and scientists was convened in May, 2008 at the University of Pennsylvania, for a full day of discussion. Out of these discussions, the following points were distilled:

Diffuse purulent perforating peritonitis was diagnosed in 41 children aged from 6 hours to 14 years old, including up to 1 year - 15 children (36,5%), 1-4 years old - 1 child, 4-7 years old in 8 children (19%%), 7-14 years old inl8 children (45%). Bowel perforations were caused by complications of diseases and malformations and acute purulent processes in the abdominal cavity. Perforating peritonitis has polymorphism of pyogenic flora, where the most dangerous are the following: Pseudomonas aeraginosae, fungi Candida (albicans, crasei, glabrata, tropicalis), Klebsiella pneumoniae, Enterococcus faecium, Enterobacter cloacae; E.Coli, Staphylococcus pyogenes, Staphylococcus aureus rarely revealed in the children after 4 years of age. The paper focuses on ineffective traditional treatment of children with diffuse perforating peritonitis due to insufficient knowledge of the pathogenesis of the disease and low efficiency of remedial measures. The authors´ developments aimed at improving efficiency of the local rehabilitation of purulent perforating peritonitis continue to be implemented in practice. However, the methods of differentiated treatment of patients with purulent perforating peritonitis are missing in clinical practice. The use of new medical technologies in complex diagnostics and the modern antifungal and highly effective antibacterial drags in treatment of patients contributed to improve treatment outcomes and prevent mortality.

67 purulent peritonitis children (excluding newborns) aged of from 1.5 months to 15 years treated in the hospital from 2007 to 2016 for gastric or intestinal perforation at different levels were examined. These children were divided in 2 groups of patients with purulent peritonitis, matched for the gender, age and severity of the disease. The control group of the examined patients comprised 36 children, who were treated in the period of 2007-2012 for a purulent peritonitis of non-appendiceal genesis. The main group of cases included 31purulent peritonitis patients with perforation of the stomach or intestines, who was treated during the period of 2012--2016. In all 67 patients in both groups, the causes of perforation of the hollow organs - the stomach, small intestine or large intestine - with the development of purulent peritonitis were detected and remained the same for years. The severity of the course of purulent peritonitis of non-appendiceal genesis and the difficulty of treating such patients mostly depended on the patient’s age, disease nosology and background diseases. The basis for successful implementation of the treatment is the difference in the etiology of the disease and the degree of danger of the pathogen of the purulent process, depending on the level of perforation of the intestinal tube. Virulence of the pathogen and antibiotic susceptibility of purulent mono- or mixt-infection significantly influenced the severity of purulent peritonitis and the outcome of the treatment. The authors developed and proposed a complex of the differentiated etiopathogenetic treatment of patients with purulent peritonitis of non-appendiceal genesis with a decrease in the mortality rate. The basis for the successful implementation of the treatment is the difference in the etiology of the disease and the degree of danger of the pathogen of the purulent process, depending on the level of perforation of the intestinal tube.

The article considers the history of the pediatric surgery department of N. N. Burdenko Voronezh State Medical University. The department was founded in 1947. Based on the results of the research undertaken by associates of the department by now, 3 manuals for doctors and students and 12 collections of scientifc papers were issued and 12 investor’s certifcates were obtained. The role of the Student’s scientifc circle was noted: the students struck 5 gold medals during the last fve years. During the last 8 years, the scientifc circle was considered the best and was awarded a gold medal and frstclass honours degree. A close interrelation between the research work of associates of the pediatric surgery department and practical work of pediatric surgeons from the Central Black Earth region was underlined.

Anna A. Rusanova (March 8, 1907 - May 5, 1991) - surgeon, teacher, professor (1961), Doctor of Medical Sciences (1961), memoirist.Graduated from the Medical Faculty of Voronezh State University (1929). During the Great Patriotic War, he was a military doctor. Dean (1944-1974), Head of the Department of Pediatric Surgery at the Pediatric Faculty of Voronezh State Medical University (1961-1972). Author of more than 100 scientific papers, including the book "Clinic and treatment of closed craniocerebral trauma" (1974). Author of posthumously published poems, documentary stories, memoirs.