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«Atom» software is used in integrated spectral devices for atomic emission and atomic absorption analysis produced by «VMK-Optoélektronika». Development of the new spectral instruments and upgrading of existing devices, birth of new mathematical methods and algorithms for processing spectral information, as well as user stories motivate and promote improvement of the software. This paper presents the main developments and most noticeable changes in «Atom «software for the period 2017 – 2018. The developed 64-bit version of «Atom» software removed the limitation on the amount of recorded sequences of spectra and significantly speeded up their processing by parallelizing the calculations on the processor cores (rather important step, for example, in scintillation atomic emission spectrometry). To implement continuum source electrothermal atomic absorption spectrometry for simultaneous multi-element analysis, we have developed the «Automatic Dispenser» and «Absorption Spectrometer» tools and have implemented the method proposed by D.A. Katskov to linearize calibration dependences in a wide range of concentrations. The possibility of spectrophotometric determination of substances in the solutions of their mixtures has been also implemented. The «Barcode Scanner» and the «Automatic Start of Measurement» tools have been developed to speed up and automate the analysis procedure. The software is supplemented with a set of useful functions designed for further development of analytical methods and programs of analysis.

Purpose. To reflect the current understanding of the frequency, molecular mechanisms, and means of overcoming alopecia in cancer patients, taking into account the fundamental data of recent years on the physiology of the hair follicle and the pharmacological profile of the toxicity of anticancer drugs.Material and Methods. A literature search using Medline, Pubmed, etc. databases was carried out. More than 200 publications devoted to the study of alopecia were found, of which 42 were included in this review.Results. Chemotherapy-induced hair loss is a common adverse effect in cancer patients undergoing treatment. The frequency and molecular mechanism of the development of alopecia are related to the pharmacological features of the drug-based treatments, initial nutritional premorbid status, and predisposing polymorphisms of genes involved in drug conversion and excretion. Focal or diffuse alopecia may be the first sign of malignant growth within the paraneoplastic syndrome, primary or metastatic malignancies of the scalp, or be a manifestation of nutritional insufficiency. Baldness negatively affects the psycho-emotional state of patients, exacerbating depressive disorders, anxiety, reducing self-esteem and adherence to treatment. Thus, prevention or rapid overcoming of alopecia can significantly improve the quality of life of cancer patients. The use of scalp cooling or ‘cold caps’ is proven to be an effective way of combating chemotherapy-induced hair loss.Conclusion. Further studies are needed to prevent and treat alopecia in cancer patients.