We studied the effect of a single session of hyperbaric oxygenation on the size of risk, ischemic, and necrotic zones in rat myocardium after irreversible occlusion of the coronary artery and excessive oxygen pressure of 0.02 and 0.1 MPa. Myocardium infarction was reproduced by ligation of the left coronary artery. The size of the risk, ischemic, and necrotic zones was planimetrically evaluated. Hyperbaric oxygenation (60-min session) was performed 3 h after artery occlusion at excessive oxygen pressure of 0.02 and 0.1 MPa. In rats not exposed to hyperbaric oxygenation, the risk zone median was 31.7% of the left ventricle weight, while after the session it did not exceed 25%. In spontaneous course of myocardium infarction, the ischemia to necrosis zone ratio was 1.7:1, while under conditions of hyperbaric oxygenation at oxygen pressure of 0.1 and 0.02 MPa, the these values were 0.6:1 and 2:1, respectively. Excessive oxygen pressure of 0.02 mPa is better than traditionally used 0.1 MPa, because it promotes redistribution of the ischemic and necrotic areas in the risk zone: the area of necrotic zone decreased at the expense of the ischemic zone. Hyperbaric oxygenation produces a positive effect on the myocardium under conditions of total occlusion of the coronary artery.

Саливончик Дмитрий Павлович (Dimitry P. Salivonchyk)* -доктор медицинских наук, доцент, заведующий кафедрой внутренних болезней № 3 с курсом функциональной диагностики УО «Гомельский государственный медицинский университет»,

The information about the modern medical treatment of the acute coronary syndrome was presented in the this review.

Administration of hypobaric oxygenation in subacute period of myocardial infarction before the aortocoronary bypass (one session, duration 60 min, working pressure 0,03 MPa) and after discharge from emergency department (5 sessions) allows to improve significantly integral score of physical component of health (SF-36) in main group (from 23,0 ± 1,6 to 53,6 ± 3,6; level of this score in control group shifted from 16,0 ± 1,2 to 40,6 ± 1,9; p = 0,028); integral score of mental component of health (from 31,0 ± 1,7 to 54,2 ± 2,9 in main group; from 24,3 ± 1,2 to 39,6 ± 2,1 in control; p = 0,017).

HBO is pathophysiology based method in the medical treatment of the ischemical cardiovascular diseases. The application of the HBO in the «little» regimes in the ischemical disease of the card has important advantage in comparison with «high» regimes hyperoxii.