Link for citation: Lukutin B.V., Muravyev D.I. Optimization of operational control of autonomous photo-diesel power supply system with DC bus. Bulletin of the Tomsk Polytechnic University. Geo Аssets Engineering, 2022, vol. 333, no. 4, рр. 224-235. In Rus. The relevance. An increase in the contribution of renewable energy sources to the generation of the autonomous hybrid energy industry is important in order to reduce the environmental impact of diesel generator plants and decrease operating costs in the production of electrical energy in smart microgrids with distributed generation, including so-called «green» generation. This issue has the highest relevance for cell towers of mobile communication, rotational residential camps, meteorological stations and other remote consumers, the rated capacity of which is tens to hundreds of kW. Objective: the development of computer models for optimizing the management of the operational staff and modes of an autonomous photo-diesel power supply system with a DC bus, so as to make it possible to minimize the operating time of a diesel generator plant by increasing the contribution of the photovoltaic plant at optimal technical and economic indicators. The use of a DC bus for the electricity integration from distributed energy sources is considered promising in reducing the number of hours of inefficient operation of a diesel generator plant, which will make it possible to save diesel fuel and extend the life expectancy of the diesel generator. Novelty. This work expands the known options for modeling and optimizing the modes of a standalone hybrid DC power plant in terms of using an objective function with appropriate restrictions, adapting models of power equipment for the intended purposes of modeling, presenting the structure of a feasibility study based on commercially available characteristics of the elements of the power supply system. Methods. The study entails the development of computer models of the intelligent control architecture of a standalone hybrid power plant including a photovoltaic plant, a diesel generator plant, an electric energy storage system, a remote consumer, as well as auxiliary converter devices. Modeling of control processes is implemented in the Stateflow library, as well as by using the language syntax of the Matlab high-level package, the capabilities of which are acceptable for the intended purposes. Results. The analysis of the results shows that DC PV-diesel power supply systems can be cost-effective in all scenarios that include different types of batteries while for systems without power storage, DC distribution is often not cost-effective. The results will be of interest to specialists developing or operating standalone power supply systems and organizations planning to upgrade existing diesel power plants.