Epilepsy is one of the most frequent neurological disorders. In these circumstances, more than 25% of the patients are women of reproductive age. The aim of our research was to analyze the effectiveness and safety of antiepileptic therapy in women with epilepsy during pregnancy and to analyze the pregnancies' outcomes. We included in our research 121 pregnancies of 101 women aged at the moment of childbearing about 26.9 ± 4.57 years old. Idiopathic forms of epilepsy were predominant among all causes-47.1% (р < 0.01). Of all cases, 65.4% remained seizure-free from generalized tonic-clonic seizures (GTCS), including 69.6% of all idiopathic epilepsy cases and 68.6% among symptomatic ones. The antiepileptic drugs (AED) dosages were exceeding teratogenic level at the moment of conception in 54.7% of the cases. Worse control of epileptic seizures was associated with Benzobarbital (66.7%) and Lamotrigine (50.0%). Women with epilepsy did not receive specialized neurological therapy before conception in most cases, which leaded to the usage of AED teratogenic doses and less effectiveness of AED during pregnancy. It is necessary to plan the pregnancy and prescribe rational treatment for epilepsy starting at the stage of planning and during gestation in order to obtain a better seizures control and to decrease congenital disorders risk in fetus.

Juvenile myoclonic epilepsy (JME) is one of the most common types of idiopathic generalised epilepsy. It starts in teenage years, yet it is frequently misdiagnosed or diagnosed very late, thereby resulting in inadequate therapy plan and worsening of symptoms. Timely diagnosis of JME is crucial for the correct management of symptoms and prevention of disease development. In this case report we describe a case of a 33-year-old woman who did not receive appropriate care due to a late diagnosis of her JME condition.

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We present a study of disorder origination and growth inside an ordered phase processes induced by the presence of multiplicative noise within mean-field approximation. Our research is based on the study of solutions of the nonlinear self-consistent Fokker-Planck equation for a stochastic spatially extended model of a chemical reaction. We carried out numerical simulation of the probability distribution density dynamics and statistical characteristics of the system under study for varying noise intensity values and system parameter values corresponding to a spatially inhomogeneous ordered state in a deterministic case. Physical interpretation of the results obtained that determines the scenario of noise-induced order-disorder transition is given. Mean-field results are compared with numerical simulations of the evolution of the model under study.We find that beginning from some value of external noise intensity the "embryo" of disorder appears inside the ordered phase. Its lifetime is finite, and it increases with growth of noise intensity. At some second noise intensity value the ordered and disordered phases begin to alternate repeatedly and almost periodically. The frequency of intermittency grows with the increasing of noise intensity. Ordered and disordered phase intermittency affects the process of spatial pattern formation as a consequent change of spatial inhomogeneity configurations.

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