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The article is dedicated to contemporary views on the change of endothelial function in the patients with lymphoproliferative disorders prior to, and in the process of, chemotherapeutic treatment. Considering that possibilities of standard examination do not always help identifying subclinical endothelial dysfunction, it is necessary to use specific methods, in particular, to determine the levels of endothelin-1 and vascular endothelial growth factor to monitor endothelial function. The objective of this review is to identify problems and prospects for recognizing early subclinical changes of endothelial function in the patients with lymphoproliferative disorders before and after chemotherapy. Assessing presence and severity of endothelial dysfunction may be useful for determining subclinical stages of cardiovascular damage, stratifying the risk of the patients with confirmed cardiovascular disease, and reducing the likelihood of cardio- and endotheliotoxic effects in patients long after chemotherapy. That is why early detection and immediate therapy of cardiovascular toxicity is currently the most important task in the patients with lymphoproliferative disorders, receiving chemotherapy.

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Abstract. The goal of our study was to estimate the accuracy of measuring the blood haemoglobin concentration by means of the pulse CO-oximetry, depending on the probe radiation wavelength. Revealing the combinations of wavelengths, optimal for minimising the measurement error, will allow the formulation of requirements to the instruments for noninvasive assessment of haemoglobin concentration, applicable in wide clinical practice. To solve this problem, we examined a group of haematological patients in the Haematology Department of the Samara State Medical University Clinic with the aim to compare the results obtained using the experimental multiwave system for noninvasive haemoglobin concentration assessment and the results of the clinical blood analysis.

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