Reduced heart rate variability (HRV) is associated with the elevated mortality rate in patients with cardiovascular disease. Risk factors, in terms of the negative impact on the cardiovascular system of workers of oil production include noise, vibration, the severity of the labor process, climate, lighting, and various chemicals presenting in the working area (the total of various hydrocarbons, including aromatic hydrocarbons, disulfide sulfur). HRV indices were recorded daily by Holter monitoring. Employees with the work experience at oil production from 10 to 20 years were established to have a statistically significant increase in tone of the sympathetic nervous system, characterized by the decline ofpNN50 by 2.2 times and the increase of the vagal tone, characterized by an increase in SDANN by 1.4 times and SDNN - by 1.3 times. A significant dependence of the probability of the increasing of the tone of the sympathetic nervous system from work experience was established. Thus, the impact of hazards of oil-producing enterprise is associated with prognostically unfavorable changes in HRV. These changes may exacerbate hypertension in employees, which requires measures for the primary prevention of cardiovascular diseases.

Introduction. The relevance of the study of cardiovascular diseases (CVD) as a production-related pathology in workers at industrial enterprises is due to the presence in the technological process of production factors (noise, general vibration, microclimate, severity of labor, chemical factors), potentially capable of provoking the development of CVD.The aim of the study was to assess respiratory and metabolic disorders, which are risk factors for CVD, in workers exposed to dust, chlorine and hydrogen chloride.Materials and methods. 139 patients working under the influence of dust, chlorine and hydrogen chloride were examined. Among the surveyed 74 women and 65 men. The comparison group (45 people) consisted of 20 women and 25 men who were not exposed to harmful factors of production during their working life.Results. In the group of workers exposed to occupational exposure to dust, chlorine and hydrochloride vapors, it was revealed that the proportion of workers with arterial hypertension was 33.3%, in the comparison group–17.6%, p<0.05 (RR 1.99; 95% CI 1.01–3.93; EF=47%; the degree of professional conditioning is average). The volume of forced exhalation per 1 second (FEV1) in the observation group was 3.18±0.14 l, and in the comparison group–4.1±0.20 l (p<0.001). The level of total cholesterol in the observation group was 5.72±0.13 mmol / l, and in the comparison group–5.16±0.23 mmol / l (p<0.05). The observation group showed a decrease in HDL (1.35±0.04 mmol / l vs. 1.64±0.10 mmol / l in the comparison group, p<0.05) and an increase in triglycerides (2.3±0.17 mmol/l versus 1.51±0.16 mmol/l in the comparison group, p<0.05).Conclusions. In the group of workers exposed to professional dust, chlorine and hydrochloride vapors, a decrease in the speed parameters of the external respiratory function, the development of proatherogenic metabolic disorders, and an increase in laboratory indicators of inflammation were revealed. These changes can lead to early manifestation of cardiovascular and respiratory pathology in this category of workers.

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In medical specialties there are psycho-social factors. Among the distress factors prevail physiological. The main factor contributing to the formation of the CMEA among medical workers is a lack of free time, which leads to fatigue and reduced interest in work.

The article describes the risk factors, peculiarities of the production exposure, changes in laboratory and functional indices in the presence of the development of respiratory diseases in workers occupied in titanium and magnesium production. The obtained data of the present study demonstrate the availability of both the early diagnosis on the stage of the prenozological states and efficient preventive measures.