Copolymer 1 (Cop 1) is a synthetic basic random copolymer of amino acids that has been shown to be effective in suppression of experimental allergic encephalomyelitis and is being tested as a

No abstract

Monoclonal Abs to the complex formed between human MHC class II molecules (DR7 and DRw11) and myelin basic protein (MBP) were produced. The specificity of these Abs was established by both FACS analysis and complement-mediated cytotoxicity of MBP- or OVA-pulsed human APC of the same or of different DR restriction. These Abs bound to and lysed only MBP-pulsed human APC of the same DR restriction (DR7 or DRw11) but not to APC of different DR restriction or pulsed with a different Ag (OVA). The physiologic role of these Abs was further investigated. They blocked the in vitro proliferative response to MBP-specific T cell clones isolated from multiple sclerosis patients in an antigen-specific and DR-restricted manner. However, the Abs did not affect the response of MBP-specific T cell clones of other DR restriction nor did they interfere with the response to other Ags (purified protein derivative or copolymer 1) presented on APC with the same DR restriction. These Abs may be useful for treating multiple sclerosis in which reactivity to MBP is implicated. Moreover, this approach may be extended to other autoantigens and their counterpart autoimmune diseases.

The objective of our study was to study the indicators of oxidative and hydrolytic enzymes of blood leukocytes in the dynamics of adenovirus infection in comparison with the duration of circulation of adenoviruses in the body. For this purpose, the activity of acid and alkaline phosphatase (AP and ALP), succinate dehydrogenase (SDH), the content of glycogen (G) in leukocytes, as well as the duration of the luminescence of adenoviral antigen in epithelial cells of the nose were determined by direct immunofluorescence. In addition, a serological study of paired blood sera from the same patients was carried out by staging a complement fixation reaction (CSC).