The author provides current data about mechanisms of the damaging effect of ultraviolet rays on our skin as well as describes constitutional skin phototypes (based on the Fitzpatrick scale) and clinical stages of skin photoaging (based on the Glogau classification system). The author assessed the extent of changes in the cell structure at different epithelial tumors of skin developing against the background of progressing skin photoaging. The study used molecular markers showing the extent of proliferative activity and differentiation of keratinocytes (anti-Ki67 antibodies, PCNA, P53, Bcl-2, matrix metalloproteinases MMP-1, -9 and their endogenous inhibitors Т1МР-1 ,-2) as their interpretation helps understand the processes of induction and promotion of oncogenesis induced by ultraviolet rays. The author also describes methods of photoaging prevention and treatment.

According to the criteria of the world health organization, the geriatric population is people who have reached the age of 60 years. Biological aging is accompanied by a progressive decrease in the functional and reserve capabilities of all structural elements of the skin, is a complex process and the result of the influence of both non-modifiable (chronological aging, ethnicity and natural anatomical changes) and modifiable factors (hypoestrogenation, exposure to ultraviolet rays, stress, etc.) Dermatoses occurring with the defeat of the anogenital region in the geriatric group of patients are a big problem not only for diagnosis and treatment, but also significantly worsen the quality of life of patients. Extensive lesions of the anogenital zone are one of the characteristic clinical signs of limited scleroderma, in particular one of its clinical variants — scleroatrophic lichen. (Lichen sclerosis and atroficus). Scleroatrophic lichen (SL) is a chronic autoimmune dermatosis, occurring with a predominant lesion of anogenital tissues, in 85–93 % of cases in women and men.

Clinical cases of cutaneous eruptions in patients with new coronavirus infection (COVID-19) are described. The authors conclude that predominant morphological eruptions in the form of macules, papules and weals are associated with COVID-19. As a rule, eruptions occur simultaneously with the onset of the first signs of the disease or several days later both in adult and children. The severity of COVID-19 does not generally correlate with the severity of skin clinical manifestations. The skin eruptions are most frequently difficult to attribute to a particular diagnosis, and they are often diagnosed as some kind of dermatosis. Skin eruptions regress quite shortly due to COVID-19 treatment and improvements in the patients general condition as well as the use of topical steroids, or even without treatment.

This review examines the psychosomatic aspects of pruritus in dermatological practice, as well as chronic dermatoses associated with pruritus of psychosomatic disorders in a lichen planus model. As the leading nosogenic factor, skin itching is involved in the development of psychogenic, neurotic, and depressive disorders. Notably, psychosomatic disorders associated with itching form various comorbidities with phenotypic manifestations of lichen planus. The introduction of an integrated multidisciplinary approach into the clinical practice, with the inclusion of psychocorrectional techniques in basic dermatological treatment, can help to optimize the course of skin disease. The modern domestic and foreign sources of literature were reviewed.

Background: The authors presented their own experiences of skin restoration in patients with rosacea after a course of active therapy using transdermal redermalization. Aim: The course of cosmetic correction procedures using this method aimed to restore the energy potential of cells, water balance, and structures of the dermal elastin fibers, normalize microcirculation processes, and create an optimal physiological environment for the mitotic activity of epidermal cells. Materials and methods: An innovative method of transdermal redermalization represents the administration of a drug containing hyaluronic acid and sodium succinate using the technique of papular intradermal injections, taking into account the peculiarities of lymphatic drainage in the facial area. Results: To assess the therapys efficiency, noninvasive monitoring of changes in morphological structures of the skin was performed using confocal laser scanning microscopy. Conclusions: The authors revealed the high efficiency of the method, which controls the remission state for a long term, subsequently avoiding drug therapy