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Creation of osteoinductive materials based on biocompatible synthetic salts, with a sufficiently high strength and porosity, with the shape which allow filling bone defects with various shapes and sizes is an actual task of modern biomaterial science. In this work, a series of granular materials were obtained from synthetic powders with various proportions of hydroxyapatite and wollastonite using a suspension technology based on the principle of immiscible liquids. Ceramic particles have a spherical shape, microhardness at least 17 HV and open porosity about 50 %. These materials can be used for reparation of bone defects of various locations, shapes and sizes in surgical dentistry, traumatology and orthopaedics.

The regularities of nucleation in model solutions of oral cavity have been investigated, and the induction order and constants have been determined for two systems: saliva and dental plaque fluid (DPF). It is shown that an increase in the initial supersaturation leads to a transition from the heterogeneous nucleation of crystallites to a homogeneous one. Some additives are found to enhance nucleation: > C 6 H 12 O 6 > F -, while others hinder this process: protein (casein) > Mg 2+ . It is established that crystallization in DPF occurs more rapidly and the DPF composition is favorable for the growth of small (52.6-26.1 μm) crystallites. On the contrary, the conditions implemented in the model saliva solution facilitate the formation of larger (198.4-41.8 μm) crystals.

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