Objectives. The objective of this study is to compare different methods of combination general and regional anesthesia based on xenon.Materials and methods. Xenon anesthesia combined with epidural block was performed in 50 children with cerebral palsy aged 3–17 years. In 30 patients xenon was used to maintain anesthesia, in 20 children xenon was combined with sevoflurane. We compared the process of anesthesia, the intraoperative hemodynamic parameters and cognitive status before surgery and after it.Results. The use of xenon in all studied anesthesia methods increased the cardiac performance and was associated with a stable hemodynamic profile at all stages of anesthesia despite the depressive effect of epidural blockade on hemodynamics. Psychological testing revealed that xenon anesthesia has no negative effect on cognitive functions in children with cerebral palsy.Conclusion. Xenon anesthesia is a promising trend in anesthesia care for children with cerebral palsy. Xenon can compensate the hemodynamic depression caused by epidural anesthesia due to its cardiac stimulant property, with no neurotoxicity being a significant benefit for children with initial damage of CNS. However, anesthesia with xenon turned out to have some disadvantages. In our study, xenon showed insufficient analgesic properties, had emetic properties and was associated with spirometric abnormalities. It was more difficult to maintain normal ventilation parameters in young children when using xenon. Several adverse events were noted in the recovery period. These disadvantages can be partially reduced by using a combination of xenon and sevoflurane.