Very low (nano- and subnanomolar) concentrations of 10-(6'-plastoquinonyl) decyltriphenylphosphonium (SkQ1) were found to prolong lifespan of a fungus (Podospora anserina), a crustacean (Ceriodaphnia affinis), an insect (Drosophila melanogaster), and a mammal (mouse). In the latter case, median lifespan is doubled if animals live in a non-sterile vivarium. The lifespan increase is accompanied by rectangularization of the survival curves (an increase in survival is much larger at early than at late ages) and disappearance of typical traits of senescence or retardation of their development. Data summarized here and in the preceding papers of this series suggest that mitochondria-targeted antioxidant SkQ1 is competent in slowing down execution of an aging program responsible for development of age-related senescence.

The effects of He-Ne laser irradiation (including visible laser light 632.8 nm in wavelength and an attendant electromagnetic field from the laser apparatus) on the fertility, newborn quality and linear dimensions of the body of Cladocera Daphnia magna Straus were determined. It is shown that the attendant electromagnetic field generated by the laser apparatus can have significant impact on the results of low-intensity laser therapy. The laser light exposure of daphnia to a dose range of 1.7-1300 mJ cm −2 stimulates the integral functions of the daphnia's body. At the same time, the attendant electromagnetic field (72 mA m −1 in the frequency range of 0.02-20 kHz and 400 mA m −1 in the frequency range of 3-4 MHz) causes the appearance of quickly dying and/or abnormal newborn (up to a small percent) that has never been observed in the control. Anomalies of daphnia mainly consisted of swimming antenna pathologies. Moreover, under the influence of the attendant electromagnetic field on parental daphnia only, these anomalies appear even in several subsequent generations of newborn. The negative impact on daphnia disappears completely after the suppression of the attendant electromagnetic field to laboratory background level. It is shown that laser light can partially compensate the negative impact of the attendant electromagnetic field on Daphnia.

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