Background. In recent decades, diagnostic and therapeutic procedures related to classical orthopedics, manual medicine and osteopathy have become widespread in Russian clinical medicine. Osteopathy expands the possibilities of diagnosis and treatment of various diseases due to the fact that its methods are not addressed to individual symptoms of the disease, but to violations of the system organization of physiological functions of the body and to establishing cause-and-effect relationships between mechanical damage of human tissues and the development of subsequent pathologies. Currently, the problem of studying the relationship of indicators of the osteopathic status of preschool children having perinatal signs of dysarthria is relevant for osteopathic doctors. Materials and methods. On the basis of the department of osteopathy of the Yaroslav-the-Wise Novgorod State University and the V.L. Andrianov Institute of the osteopathic medicine, a study was conducted aimed at assessing the clinical and physiological parameters of children aged 2.5 to 4.5 years with dysarthria and further substantiating the effectiveness of oteopathic treatment of adverse functional disorders of the brain that affect oral speech. The work used a computer electroencephalograph Mizar. Ultrasound dopplerography of the brain vessels of the subjects using the transcranial dopplerography device EME/Nicolet as well as ultrasound examination of the cervical spine was performed. The materials obtained in the course of the study were subjected to mathematical and statistical processing using the Statistica 6.0 software package, nonparametric (Wilcoxon test) and parametric methods were used with applying the Students t-test to assess the reliability of differences, and correlation analysis was performed to establish the relationship between clinical, physiological and osteopathic indicators in children before and after treatment. Conclusions. The results of the assessment of the clinical and physiological parameters of the subjects allowed us to infer that the osteopathic treatment was effective.