Aim. To study the incidence and mortality of lung cancer (LC) in the Tomsk region and to assess the economic damage. Materials and methods. The population-based cancer registry data collected at Tomsk Regional Cancer Center and the Federal State Statistics for 2007-2017 were used. The extensive, intensive and standardized variables were analyzed. Results. LC was the 4-th most common cancer, comprising 10.4% (10.1% in the RF) of all cancer cases in the Tomsk region in 2017. It ranked as the first most prevalent cancer for men (17.0%) and the 6-th for women (4.7%). The LC incidence rate decreased by 19.6%, reaching 29.5±1.3 per 100 000 (р=0.0149). It decreased in men (р=0.0006) but was stable in women. In 2017, the lifetime risk of cancer was higher in the Tomsk region than that in the RF, being 7.3% for men and 1.5% for women. LC was the most common cause of mortality from cancer for both sexes (18.9%), being the most common in men (28.1%) and the 4-th most common in women (8.0%). The mortality rate was higher in men than in women (55.6 versus 6.0; р=0.0012). In 2016, the total loss of the life potential in men amounted to 8.4 thousand, for women - 2.5 thousand man-years. Economic damage in the form of conditionally non-produced national income was growing and in 2016 amounted to 263.7 million rubles. Conclusion. Epidemiological analysis of LC in the Tomsk region indicates the relevance of improving the anticancer struggle with the development and implementation of ideas aimed at increasing the cancer literacy of the population and the alertness of primary care physicians, the formation and monitoring of risk groups, the timely routing of patients with suspected cancer.

Научно-исследовательский институт онкологии, ФГБНУ «Томский национальный исследовательский медицинский центр Российской академии наук», г. Томск; 2 ФГБОУ ВО «Сибирский государственный медицинский университет» Минздрава России, г. Томск; 3 ФГБОУ ВО «Северный государственный медицинский университет» Минздрава России, г. Архангельск; 4 ОГАУЗ «Томский областной онкологический диспансер», г. Томск В Сибирском федеральном округе (СФО) высокий уровень урбанизации (73,1 %). В СФО входит 12 субъектов с городами-административными центрами:

Background. Pseudosarcomas of soft tissues can cause diagnostic and treatment challenges. On the one hand, it is difficult to make a nosological diagnosis based on a biopsy specimen of a tumor; on the other hand, it is difficult to determine the most appropriate treatment strategy based on a histological pattern.The purpose of the study was to analyze available literature data and systematize the histological characteristics of the chondroid lipoma and pseudosarcoma.Case description. We present the case of chondroid lipoma in a 57-year-old female patient with atypical clinical symptoms. This case shows the difficulties of differential diagnosis of soft tissue sarcomas. Using a clinical example of chondroid lipoma, a rare soft tissue tumor, and an analysis of literature data, the authors showed the importance of a detailed study of the obtained material, a qualified description of the morphological picture, in those cases when the diagnostic conclusion cannot be unambiguous about the malignancy of the tumor process. Additional biopsy is not always possible to clarify the histotype of the tumor. The presented observation shows the difficulties of differential diagnosis of soft tissue sarcomas. Minimally invasive biopsy provides no a full appreciation of histological structure; therefore, if there is a suspicion for chondroid lipoma, it is necessary to perform total surgical biopsy followed by a morphological study using the immunohistochemical method.

Introduction. A significant component in the system analysis of anti-cancer activities is the assessment of the impact of mortality on life expectancy, which indicates the social and economic situation in the region.Material and methods. The economic damage caused by laryngeal and lung cancer mortality in the Tomsk region for the period 2005–2016 was analyzed using the database of the regional cancer registry and local agency of federal state statistics service of the tomsk region.Results. The loss of the male working population ranged from 106.0 (2012–2013) to 161.5 (2008–2009) person/years of lifetime from larynx cancer and from 1058.5 (2013–2014) to 1576.3 (2006–2007) person/years of lifetime from lung cancer. The female working population lost up to 34.0 (2013–2014) person/years of lifetime due to mortality from larynx cancer and from 1445.3 (2005–2006) to 2553.9 (2015–2016) person/years of lifetime from lung cancer. The average number of undelivered years in working age due to the premature death of one man averaged 6.1 ± 2.0 years from larynx cancer and 11.1 ± 1.3 from lung cancer, one woman averaged 4.6 ± 0.9 years from larynx cancer and 6.2 ± 0.3 years from lung cancer. Economic losses associated with mortality from cancer of the respiratory system amounted to 2.251.97 million rubles: 202.07 million rubles from laryngeal cancer and 2.049.90 million rubles from lung cancer.Conclusion. The quantitative analysis of social and economic losses associated with mortality from cancer of the respiratory system enables the regional health authorities to develop and implement anti-cancer interventions to maximize the use of funds for the prevention, treatment and rehabilitation of cancer patients.