Îáçîðíàÿ ñòàòüÿ âêëþ÷àåò îáîáù¸ííûå äàííûå ëèòåðàòóðû îá ýêñïåðèìåíòàëüíîé îöåíêå âîñïðèèì÷èâîñòè Francisella tularensis ê ñóùåñòâóþùèì àíòèáèîòèêàì è èõ ýôôåêòèâíîñòè ïðè ëå÷åíèè òóëÿðåìèè ÷åëîâåêà. Ïðåäñòàâëåíû äàííûå î ñïîñîáàõ ïîâûøåíèÿ ýôôåêòèâíîñòè íåêîòîðûõ àíòèáàêòåðèàëüíûõ ïðåïàðàòîâ, ïðîÿâëÿþùèõ ñíèaeåííóþ àêòèâíîñòü ïðè òåðàïèè òóëÿðåìèéíîé èíôåêöèè. Îáîçíà÷åí ñïåêòð èññëåäîâàíèé, íàïðàâëåííûõ íà ñîçäàíèå ñîâðåìåííûõ áîëåå ðåçóëüòàòèâíûõ àíòèáèîòèêîâ, îáëàäàþùèõ íîâûìè ìåõàíèçìàìè äåéñòâèÿ. Îïèñàíû íåêîòîðûå ñïîñîáû ìîäèôèêàöèè âàðèàíòîâ óaeå èçâåñòíûõ ãðóïï àíòèáàêòåðèàëüíûõ ïðåïàðàòîâ, à òàêaeå ñïîñîáû ïðåäîòâðàùåíèÿ èëè çàìåäëåíèÿ ôîðìèðîâàíèÿ àíòèáèîòèêîðåçèñòåíòíîñòè ó F.tularensis.
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