In order to systematically collect reports on the results of the software, a unified information system, the EIS «Labor Medicine» was used. The creation of a single interdepartmental information portal allowed monitoring the conduct of mandatory preliminary and periodic medical examinations with the posting of its results on the site.

Objective: to assess the nature of changes in the level of neuron-specific enolase (NSE) in children suffering from chronic gastroduodenitis, depending on the severity of the disease, gender and physical development indicators.Materials and methods. The study group included 154 children aged 8–15 years with chronic gastroduodenitis. The main group includes children with superficial gastroduodenitis (group I) and erosive gastroduodenitis (group II). The control group consisted of 56 healthy children. All children underwent an assessment of physical development. The serum NSE level was determined by enzyme-linked immunosorbent assay. It was revealed that the main parameters of the physical development of children from the control group exceeded the values of similar parameters of children of the main group. High NSE values were established in children with chronic gastroduodenitis in comparison with the control (p≤0.01). The NSE level in boys exceeded the value of the indicator in girls in the main group and in the control group. The level of NSE in girls of the main group exceeded the value of NSE in healthy girls (p≤0.05). Studying the level of NSE taking into account gender and the severity of the pathological process revealed higher rates in boys with erosive gastroduodenitis compared with the control group (p≤0.05). In the group of children with erosive gastroduodenitis, higher NSE rates were found in boys compared with girls (p<0.05).Conclusions: A high level of NSE in children with erosive gastroduodenitis and revealed gender differences in NSE concentrations in blood serum indicate the possible role of this indicator in the development of severe forms of the disease and do not exclude the possible association of the effects of this enzyme with the function of sex hormones. The quantitative values of NSE for predicting the development of chronic gastroduodenitis in children are established.

Currently, the normative acts do not define the priority and order of interaction (routing) between various types of medical examinations (examinations) working during mandatory, preventive medical examinations and medical examination. The order of action of doctors in the diagnosis of diseases at various stages of the examination has not been determined.

Проведено исследование уровня гормонов гипофиза (соматотропного и тиреотропного), надпочечников (кортизола), щитовидной железы (трийодтиронина и тироксина), поджелудочной железы (инсулина), половых гормонов (эстрадиола и тестостерона) и гастроинтестинальных гормонов (гастрина) в периферической крови у 84 мальчиков с хроническим гастродуоденитом в сочетании с гастроэзофагеальной рефлюксной болезнью, находящихся в I-III стадиях полового созревания. В группу контроля вошли 34 здоровых мальчиков. Доказана связь развития эрозивного гастродуоденита с гормональной дисрегуляцией. Выявлено снижение уровня инсулина на фоне повышения уровня тиреотропного гормона, тестостерона, эстрадиола, кортизола и гастрина. Основные изменения гормонального статуса установлены у мальчиков, находящихся во II-III стадиях полового созревания. Исследование не выявило достоверных различий уровней гормонов у мальчиков с катаральным гастродуоденитом в сравнении с группой контроля. Ключевые слова: гормоны, половое созревание, мальчики, хронический гастродуоденит. FEATURES OF THE ENDOCRINE STATUS AT BOYS WITH CHRONIC GASTRODUODENITIS IN COMBINATION WITH GASTROESOPHAGEAL REFLUX DISEASE IN THE I-III STAGES OF SEXUAL DEVELOPMENT Panova I. V., Afonina T. A. Rostov state medical University, Rostov-on-don, e-mail:okt@megalog.ru