The aim of the study was to evaluate the effect of silent myocardial ischemia on the life quality and on the frequency of occurrence and severity of depressive disorders in patients with Ischemic Heart Disease. Materials and methods. The study involved 93 persons, including 42 practically healthy individuals and 51 patients with Ischemic Heart Disease: silent myocardial ischemia. The study included males, aged 45 to 60 years old. To assess the life quality, the Russian validated version of the Medical Outcomes Study-Short Form (SF-36) questionnaire developed by the Boston Institute of Health was used. The Hamilton Depression Rating Scale (HDRS) was used to study the psycho-emotional state of the patients. Statistical data analysis was performed using the Statistica 10.0 and Microsoft Excel 2010 software package. Results. Role functioning (RF) was reduced by 32 % (p<0.0001), general health (GH) was reduced by 31 % (p<0.0001), and mental health was reduced (MH) by 32 % (p<0.0001), social functioning (SF) decreased by 30 % (p<0.0001) in patients with silent myocardial ischemia compared to healthy persons. Both integral indicators of life quality were also reduced in the patients with silent myocardial ischemia compared to the control group. The integral indicator «Physical component of health» for group I was 52.24 [37.4; 59.8] and for group II – 48.84 [41.08; 53.01], p<0.001. The integral indicator «Mental health component» for group I was 54.00 [51.45; 56.76] and for group II – 47.09 [30.29; 52.71], p<0.00001. Mild to moderate depression was found in 35.3 % of the patients with silent myocardial ischemia, and 15.68 % was with severe and extremely severe depression.Conclusions. Silent myocardial ischemia decrease the life quality of patients and promotes the development of depressive states.