This article is a continuation of a series of studies on the optimization of techniques and methods of surgical operations for hernias of the esophageal aperture of the diaphragm and is based on the use of the author's development of a model of a two-layer biocarbon mesh implant. The purpose of this study is to highlight the immediate and long-term results of using a double-layer biocarbon mesh implant in comparison with the standard method of using a polypropylene implant when operating patients with large and giant hiatal hernia.All patients were divided into 2 research groups that underwent alloplastic with various implants: Group I of 221 patients who underwent alloplasty with a polypropylene mesh implant (171 patients with large hernias of 10-20 cm2) and 50 patients with giant hernias of the esophageal orifice with the area of the hernial defect is more than 20 cm 2 ); Group II of 79 patients who underwent an original alloplastic with a bi-layer biocarbon mesh implant (50 patients with large hernias and 29 patients with giant hernia of the esophageal orifice). Postoperative complications were classified according to the Clavien-Dindo scale.The index «De Meester» was used as a comparison criterion. The article discusses the results of operations of 300 patients for large and giant hernias of the esophageal aperture of the diaphragm, of which 79 were operated on using a prototype biocarbon double-layer mesh implant according to the author's patent. The paper presents immediate and long-term results. The results of surgical treatment are pilot and representative, which determine the further tactics and direction of improving operations to remove large and giant hernias of the esophageal opening of the diaphragm. For the first time, data on the use of the author's development of a bi-layer biocarbon mesh implant are presented and compared with a polypropylene mesh implant during an «on-line» plastic repair of large and giant hiatal hernia. Significant differences were obtained in relapses of all types in favor of a biocarbon mesh implant (5,6 versus 22,8%; p < 0,0001; Fisher's exact test).

The aim of the research. The work considers the results of posterior cruraraphy along with hernioplasty, using polypropylene and biocarbon implant in surgical treatment of diaphragmatic hernias of various sizes. Material and methods. Totally 716 patients were divided into 3 study groups, based on the size of esophageal hernia defect: group I (314 people) – with small and medium size of hiatal hernias, who underwent posterior cruraphy; group II (323 patients) – with large hernias: subgroup 1 (92 patients) underwent posterior cruraphy, subgroup 2 (231 patients) – underwent hernioplasty. Subgroup 2 was divided into: subgroup A (89 people) – plastic surgery with polypropylene implant and subgroup B (142 people) – plastic surgery with biocarbon implant. Group III (79 patients) – patients with giant hiatal hernias: subgroup A (29 people) – plastic surgery with polypropylene implant and subgroup B (50 patients) – biocarbon construction. Results. While comparing group Ӏ with group II, subgroup 1 signifi cant diff erences were found in the degrees and types of hernias. Th e age of patients was not statistically important. While comparing subgroup 1 with subgroup 2 of group II, statistically insignifi cant diff erences were revealed in degrees and types of hernias. Th e age of patients was also statistically insignifi cant. While comparing subgroup A with subgroup B of group II, insignifi cant diff erences were revealed in degrees and types of hernias. While comparing subgroup 2, group II with group III, the diff erence turned out to be signifi cant in types and degrees of hernias. While comparing subgroup A with subgroup B, group III, statistically insignifi cant diff erences were revealed in the degrees and types of hiatal hernias. Conclusion. Posterior cruraphy in small and medium diaphragmatic hernias differed in types, degrees and size of hernia defect in comparison to the one in large hernias. Posterior cruraphy with plasty for large hernias did not diff er signifi cantly according to any of the criteria. Plastic surgery by polypropylene implant with biocarbon in case of large hernias did not diff er signifi cantly by any criteria. Plastic surgery for large hernias compared to giant ones, diff ered only in the degree and types, as well as in hernia defect size. Plastic surgery by polypropylene implant with biocarbon in giant hernias did not differ in any criteria, except for gender distribution, which was not signifi cant, that made it possible to compare treatment results in these subgroups more correctly.

Аннотация. В данной исследовательской работе были последовательного описаны результаты проведения двухслойной лапароскопической герниопластики при больших грыжах пищеводного отверстия диафрагмы с применением имплантата из медицинского биокарбона. Проанализированы отдалённые результаты рандомизированного исследования по оперативному лечению больших диафрагмальных грыж с площадью дефекта в 10-20 см2. С 2014 по 2020 год было прооперировано 92 пациента. В ходе операций больные были разделены на 2 исследовательские группы: 46 пациентам применялась лапароскопическая пластика диафрагмальных грыж методом задней крурорафии (I группа), другим 46 больным -пластика биокарбоновым имплантатом «Ultrapro» («Ethicon») по разработанной методике (II группа).

Aim. The article discusses the results of a study using a patented method of two-layer laparoscopic repair of large and giant hiatal hernias using a biocarbon implant in comparison with other surgical techniques. Materials and methods. 716 patients were divided into 3 study groups based on the area of the size of the esophageal hernia defect: group I (314 patients) – with small (less than 5 cm2) and medium (5–10 cm2) hiatal hernias, that is, up to 10 cm2, which hernioplasty was performed only by the method of posterior cruraphy; group II (323 patients) – with large hernias 10–20 cm2: subgroup 1 (92 patients) underwent posterior cruraphy, subgroup 2 (231 patients) – alloplasty. Depending on the alloplasty technique, subgroup 2, in turn, was divided: subgroup A (89 people) – hernioplasty with a polypropylene implant and subgroup B (142 people) – hernioplasty with a medical biocarbon construction. Study group III (79 patients) – patients with giant diaphragmatic hernias of more than 20 cm2 using alloplasty: subgroup A (29 people) – hernioplasty with a polypropylene implant and subgroup B (50 patients) – alloplasty with a medical biocarbon construction. Results. When comparing group I with subgroup 1 of group II, the following results were obtained. Statistically significant differences were found in the degrees and types of diaphragmatic hernias. The average age of patients and statistical differences for it were insignificant. When comparing subgroup 1 with subgroup 2 of group II, statistically insignificant differences were found in the degrees and types of hiatal hernias. The difference in the average age of patients was also statistically insignificant. The difference in the average age of patients was also statistically insignificant. When comparing subgroup A with subgroup B of group II, statistically insignificant differences were found among themselves in the degrees and types of hiatal hernias. When comparing subgroup 2 of group II with group III, the difference turned out to be statistically significant in the distribution of patients by types and degrees of diaphragmatic hernias. When comparing subgroup A with subgroup B of group III by degrees and types of hiatal hernias, statistically insignificant differences were revealed. Conclusion. Posterior cruraphia in small and medium diaphragmatic hernias had significant statistical differences in types and degrees compared to that in large hernias, as well as in the average area of the hernial defect. Posterior cruraphia with hernioplasty in large hiatal hernias did not differ statistically significantly according to any of the criteria. Plastic surgery with a polypropylene implant with alloplasty of a biocarbon implant for large hernias did not differ significantly according to any of the criteria. Hernioplasty for large hiatal hernias, when compared with giant hernias, differed significantly only in the degree and type, as well as in the area of the hernial defect. Onlay plastic surgery with a polypropylene implant with alloplasty of biocarbon structures for giant hernias did not differ significantly according to any of the criteria, except for gender distribution, which did not have significant fundamental significance, which made it possible to make a more correct comparison of the results of surgical interventions in these research subgroups.

Исследование не имело спонсорской поддержки. Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов. Аннотация В экспериментальном исследовании было использовано 60 особей животных. В зависимости от количества тиамина в рационе животные были разделены на следующие 3 исследовательские группы (по 20 в каждой): контрольная группа I-с нормальным рационом питания; группа II-в рационе питания полностью отсутствовал тиамин, были исключены продукты, содержащие витамин B 1 ; группа III-в рационе преобладали продукты, богатые витамином B 1. Для оценки результатов были использованы искусственное воздействие горячим потоком воздуха с шумом, установка «открытое поле», установка «приподнятый крестообразный лабиринт». В ходе экспериментов установлено, что снижение суточного тиамина негативно сказывается на когнитивных способностях, уменьшается резистентность организма к стрессовому фактору.