In the article there is presented the most complete to date information on the incidence of Crimean hemorrhagic fever (CHF) in endemic countries in Europe, Africa and Asia, with allowances made for the first publications in the 40-ies of XX century to 2012. According to available sources, the total number of cases of CHF in this period was 7924, out of which 2180 in the Russian Federation, 1820 in Turkey, 1554 in Bulgaria, 553 in Uzbekistan, 286 in China, 264 in Kosovo, 260 in Kazakhstan, 265 in Africa (including 180 in South Africa).

338 blood sera from 254 CCHF patients residing in the south endemical areas of the Russian Federation during 2003-2010 were examined with the use of ELISA-IgM (MAC-ELISA) and ELISA-IgG methods. The dynamics of specific antibodies for a month from the beginning of the disease including patients with different clinical forms of CCHF, cases of different ages, males and females has been investigated.