The present work was designed to study the influence of type 2 diabetes mellitus on the clinical course of articular syndrome in patients with combined pathology. A total of 45 patients with diabetes mellitus and gonarthrosis were examined and 45 ones with gonarthrosis without concomitant type 2 diabetes. The patients of both groups were matched for age, sex, duration and stage of gonarthrosis, and body mass index. It was shown that concomitant diabetes mellitus promotes progression of articular syndrome. Decompensation of diabetic state leads to exacerbation of pain syndrome, marked functional changes and increased severity of the inflammatory processes in the joints.