Purpose: To optimize the computed tomography protocol in pediatric Hodgkin lymphoma for radiation dose reduction by reducing the scanning phases. Material and methods: A retrospective CT scan analysis of 48 children with newly diagnosed, verified Hodgkin’s lymphoma was performed at the primary staging and after the first chemotherapy. All studies were performed with contrast enhancement, scanning on a 16-slice computed tomography in the precontrast, arterial, venous and delayed phases. The radiation dose and the diagnostic value of each phase were assessed. Results: Two-phase scanning (in the native and venous phases) for primary patients allows significantly reduce the cumulative effective dose (ED) almost in twofold. Conducting single-phase scanning can significantly reduce the received ED by 3.8 times in both the primary and dynamic studies. Using the abbreviated protocol does not reduce the diagnostic value of CT. Conclusion: The greatest number of repeated CT examination is carried out in children with lymphomas. The radiation dose increases several times in multiphase scanning. New CT protocols reduces the radiation dose on children with Hodgkin lymphoma.
Background Children with HL are forced to undergo repetitive studies accompanied by radiation, which increases radiation doses. High radiation during studies in children is a huge problem, since the risk of developing complications for patients of this age is much higher than for adults. Purpose To optimize the computed tomography protocol in pediatric Hodgkin lymphoma for radiation dose reduction by reducing the scanning phases. Material and methods CT scan analysis of 75 children with newly diagnosed, verified Hodgkin’s lymphoma was performed at the primary staging and after treatment. All studies were performed with contrast enhancement, scanning on a 16-slice computed tomography in the precontrast, arterial, venous and delayed phases. The radiation dose and the diagnostic value of each phase were assessed. Results Using the reduced CT protocol for primary patients allows significantly reduce the cumulative ED by 3.8 times and by 3.6 times for dynamic scanning. Using the abbreviated protocol does not reduce the diagnostic value of CT. Conclusion The proposed low-dose CT protocol with the reduction of contrast enhancement phases allows to obtain CT images with good diagnostic quality and reliably reduces the radiation dose to the child.
РезюмеОсновными методами, применяемыми для первичного стадирования и оценки ответа на лечение у детей с лимфомой Ходжкина (ЛХ), являются компьютерная томография с контрастным усилением (КТ с КУ) и совмещенная позитронно-эмиссионная томография с 18F-фтордезоксиглюкозой с КТ (18F-ФДГ ПЭТ/КТ). Оба метода обладают высокими показателями чувствительности и специфичности. Несмотря на это, единый диагностический протокол для детей с лимфомой Ходжкина еще не разработан. Одновременное использование двух методик на каждом лечебном этапе не всегда является целесообразным. Необоснованное последовательное проведение КТ с КУ и ПЭТ/КТ с 18F-ФДГ у детей с ЛХ увеличивает кумулятивную дозу излучения на ребенка и расход ресурсов оборудования. В данной статье детально рассмотрены основные преимущества и недостатки методов КТ с КУ и ПЭТ/КТ с 18F-ФДГ на всех этапах ведения детей с ЛХ, а также освещены различные подходы к современным диагностическим алгоритмам при первичном стадировании ЛХ у детей и оценке эффективности лечения. Поиск литературы осуществлялся с помощью следующих баз данных: Pubmed, Uptodate, ClinikalKey, CyberLeninka, РИНЦ.Ключевые слова: лимфома Ходжкина; дети; стадирование; компьютерная томография; совмещенная позитронно-эмиссионная томография и компьютерная томография; лучевая нагрузка; осложнения; обзор Конфликт интересов: авторы заявляют об отсутствии конфликтов интересов.Финансирование: исследование не имело спонсорской поддержки.
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