Background. According to the data in national literature, uveitis comprises 515% among all eye diseases. The etiological data on uveitis are still under discussion. Our aim was to decrease the percent of undefined uveitis. Methods. The first part was to collect the retrospective data on uveitis etiology (20082012). The second one consisted of examining all new patients seen in our uveitis center at the Department of Ophthalmology of the Academician I.P. Pavlov First State Medical University (20142016) with up to date methods, like laser photometry, dual angiography and other laboratory and instrumental investigational tests. Results. The percent of unknown etiology was decreased from 61,9 % to 17 %. Conclusion. The complex of modern investigational ophthalmological, laboratory and instrumental methods give the opportunity not only to diminish the proportion of undefined uveitis, but also to treat patients with more specific entities.