This article discusses the degree and usefulness of the applicability of the semiotic method in science, philosophy and academic theology. The philosophy of the semiotic method and its relationship with Orthodox theology are considered. A specific case of application of the semiotic method in Russian science in the study of theological texts in the works of S.S. Averintsev is presented and studied. It is concluded that the extensional universality of the semiotic method in all spheres of knowledge and its limitations in the ability to adequately reflect reality.