Present-day condition and objectively established trends of developing mineral and crude base of non-ferrous metallurgy have predetermined two main directions in mineral raw materials processing. The first direction is based on some traditional technologies of free-milling ore processing with receiving of mono selective concentrates at the enrichment stage with following recycling them using already known pyro-, chemico-, hydrometallurgical methods. The main way of developing this direction is invention of high-performance combined processes and combined technological schemes. The second direction covers difficult raw material. It is based on combined technologies providing a discharge of advantageous components into the mono selective concentrates at the step of enrichment. At the other steps – transfer of refractory mineral assemblages into a polymetallic products and their further selection using enrichment, pyro- and hydrometallurgical methods. Among various methods of influence on the mineral assemblages, there are two groups, applicable in combined technology systems, to highlight. These are enrichment based on energy and chemical-metallurgical impacts at the finalizing step, where the necessary increase of completeness and complexity of crude ore applying might be provided only by processing it using combined technologies, which optimally match the both of selected groups.