This article presents the results of a retrospective clinical and epidemiological analysis of acute traumatic spinal cord injury (causes, level and severity), a study of comorbid pathology and risk factors in Saint Petersburg for the period from January 1, 2012 to December 31, 2016. The obtained data are compared with similar domestic and foreign studies.

Differential diagnostics of multifocal motor neuropathy (MMN) has many difficulties associated with a number of factors: rare nature of disease, polymorphic clinical forms and a phenotypic picture similar to peripheral motor neuron diseases. Such diseases also include rare nosological forms: amyotrophic lateral sclerosis, hereditary myopathies and neuropathies; their general phenotypic picture has a form of progressive flaccid paralysis, age of the disease onset and the nature of its course. However, different pathogenesis of these diseases requires a differentiated approach to therapy. This article deals with differential diagnostics of multifocal motor neuropathy, gives examples of modern diagnostic criteria necessary for diagnosing multifocal motor neuropathy and analyzes a clinical case with an incorrect diagnosis of multifocal motor neuropathy.

This paper presents the results of retrospective analysis of 361 cases with acute traumatic spinal cord injury (TSCI) admitted to neurosurgical departments of specialized city hospitals and  Saint Petersburg Dzhanelidze Research Institute of Emergency Care from January 1, 2012, to December 31, 2016. Retrospective cohort epidemiological study allowed us to estimate the incidence rate of TSCI, age and gender characteristics and to compare data with some foreign and domestic publications. Comprehension of the incidence and structure of TSCI will improve the medical care of these patients.

In recent years, the problem of vascular cognitive impairment is becoming increasingly important due to the increasing prevalence of cerebrovascular disease. The aim of this study was to determine the relationship between 25(OH)D, highly sensitive CRP, interleukin-1, interleukin-6 and cognitive function in patients with cerebrovascular disease and to assess their impact on quality of life. Materials and methods. 58 patients with cerebrovascular disease aged 3181 years were examined. The comparison group consisted of 24 patients, comparable in age and sex, without the studied pathology. In the study, patients were determined by the level of 25(OH)D, interleukin-1, interleukin-6, highly sensitive CRP in peripheral blood. All patients underwent neuropsychological, psychometric examination and study of their quality of life. Results. In the study, the level of 25(OH)D in patients with cerebrovascular disease was lower compared to the group without this pathology. Concentrations of interleukin-1, interleukin-6, and highly sensitive CRP in patients in the main group were statistically significantly higher than in those in the comparison group. Higher concentrations of highly sensitive CRP, interleukin-1, and interleukin-6 were found in patients with low vitamin D availability. The study obtained direct correlations between the level of 25(OH)D in peripheral blood and the results of neuropsychological testing (MMSE, MoCA, FAB, Schulte tables (performance), the Drawing hours test) and the inverse with the degree of workability (Schulte tables). An inverse correlation of average strength was observed between the results of psychometric testing and the level of 25(OH)D in peripheral blood. The study confirmed the relationship between the level of 25(OH)D in peripheral blood and quality of life indicators, in the form of a direct correlation. Conclusion. The study found that the higher the concentration of 25 (OH)D and the lower the level of interleukin-1, interleukin-6, and highly sensitive CRP in the peripheral blood, the less likely it is to develop cognitive and psychoemotional disorders. The study confirmed the relationship between the level of 25(OH)D and quality of life indicators.