The aimof the work is to study the state of health and peculiarities of metabolic reactions in adolescents, representatives of the small Siberian ethnos - tofalars and caucasians.Materials and methods.Clinico-biochemical examination of children and adolescents, representatives of a small ethnic group – Тofalars and Caucasians, permanently residing in the territory of Tofalaria in the Irkutsk region. The metabolic status of adolescents was assessed using spectrophotometric (total cholesterol, diene conjugates), fluorometric (superoxide dismutase activity, α-tocopherol and retinol levels), immunoenzymes (determination of thyroid-stimulating hormone concentrations, free fractions of triiodothyronine and thyroxine, cortisol).Results. An increased incidence of diseases of the musculoskeletal system and connective tissue, as well as diseases of the endocrine system and eating disorders – among Тofalars; diseases of the genitourinary system – among Сaucasians. For practically healthy Тofalar teenagers, in contrast to Сaucasians of the newcomer population, adaptive metabolism reactions are characteristic, which is expressed by a reduced level of total cholesterol and increased values of antioxidant factors (the level of fat-soluble vitamins – α-tocopherol and retinol), and adaptive changes in the system of neuroendocrine regulation.Сonclusion. An assessment of the health status of children and adolescents in Tofalaria has shown the need for more intensive monitoring of the incidence rate in the specified region, with the obligatory consideration of the ethnic factor for the development of regional ethno-specific preventive measures.

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Установлено, что в развитых странах до 25 % подростков имеют избыточную массу тела, 15 % -страдают ожирением [4, 7,14,20]. Ранее проведён-ные биоимпедансные исследования состава тела показали стандартизованную частоту заболевае-мости ожирением у детей и подростков 5-17 лет: в 6,8 % случаев -для лиц мужского пола, в 5,3 % -для лиц женского пола [5]. В последнее время высокую распространённость данной патологии в детском возрасте связывают с изменившимися социально-экономическими условиями жизни в современном обществе, следствием которых являются нарушения нутритивного статуса и низкий уровень физической активности [11,16, 19].Исследования молекулярных механизмов форми-рования ожирения в детско-подростковом возрасте