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Background: Psoriasis is a chronic inflammatory dermatological disease that has a major impact on quality of life. Skin diseases are the most common somatic causes of psychological disorders and, conversely, under the influence of a psychological disorder, there is usually a cutaneous manifestation. This is the main reason for conducting this research during the COVID-19 pandemic, a time when most of the population is under constant stress. The research is aimed at determining the quality of life of patients with psoriasis. Materials and Methods: In this research, we employed two questionnaires. One collected particulars such as the patient's age and gender. The other was a DLQI (Dermatological Life Quality Index) questionnaire. Due to the epidemiological situation, the questionnaire was completed by patients who came for a control examination, and most of them were contacted by phone; some completed the questionnaires online. One hundred six respondents participated actively in this research. Results: The lowest score of the Dermatological Life Quality Index (DLQI) is 3, and the highest is 29. The most commonly received scores were 4 and 8, among which the score of 4 was given to 19 (17.9%) respondents and the score of 8 was given to 21 (19.8%) respondents. 69.8% of the respondents experienced problems with the affected parts of the skin rated as answers "moderately" or "a lot." In terms of health issues, female respondents had lower values than male respondents. However, by applying the t-test to determine the statistical significance of the difference with p ≤ 0.05, the value of t was determined to be-0.48 (p = 0.31), which means that there was no statistically significant difference. Conclusion: When compared to the results of studies performed several years ago, together with this study performed during the COVID-19 pandemic, there are no major differences in terms of quality of life in patients with psoriasis.

Pyoderma gangrenosum (PG) is currently considered as a reactive inflammatory dermatosis and part of the spectrum of neutrophilic dermatosis.The etiology of PG is still unknown, and its pathophysiology is far from fully understood. Inflammatory bowel disease (IBD), PAPA (pyogenic arthritis, PG and acne) and PAPA-related syndromes often develop with PG. Diagnosis largely depends on careful observation of clinical features and disease progression. We present a case of a 30-year-old patient with an ulcer on the right lower leg who does not respond to standard therapy. The patient has no other accompanying symptoms. After a complete examination, the diagnosis of ulcerative colitis is made, as a very common pyoderma gangrenosum associate disease. A complete examination of cases of ulcers that not respond to the classic therapy is required. PG treatment and diagnosis is a real challenge and requires a wide range of tests.

Venous ulcers are common in drug addicts and, although the management of these wounds is the same as in other patients, there are differences in the approach and the outcome of treatment. Those injecting drugs are at risk of serious infections, such as necrotizing fasciitis, wound botulism, and cutaneous anthrax due to the nature of the substances being injected. Herein, we present two cases of venous ulcers in drug addicts in their thirties. Both patients had been suffering from a venous ulcer for several years and the final result differed in the two patients. We concluded that it is necessary to raise awareness of the importance of treatment and lifestyle changes. The multidisciplinary approach in these patients may contribute to the improvement of wound healing.