No abstract

No abstract

The cDNA for ATPlALl -the fifth member of the human Na,K-/H,K-ATPase gene family ~ was cloned and sequenced. The deduced primary ATPlALl translation product is 1,039 amino acids in length and has M, of 114,543. The encoded protein has all of the structural features common to known catalytic subunits of P-type membrane ion-transporting ATPases and is equally distant (63-64% of identity) from the Na,K-ATPase isofonns and the gastric H,K-ATPase.The ATPl AL1 encoded protein was proposed to represent a new separate group within the family of human potassium-dependent ion pumps.

Human ATP1AL1 and corresponding genes of other mammals encode the catalytic K

The primary structure of a gene of the Na +,K+-ATPase multigenic family in the human genome has been determined. The gene corresponds to a hypothetical ~dlI-form of the enzyme catalytic subunit. The gene comprises over 25000 bp, and its protein coding region includes 23 exons and 22 introns. Possible correlation between structural features of the protein and location ofintrons in the gene are discussed.