Type 2 diabetes mellitus was modeled in newborn albino rat pups. Metabolism and contractile activity of isolated heart under conditions of hypoxia were studied on adult rats. Contractile activity of the myocardium in animals with type 2 diabetes mellitus and abdominal obesity decreased during hypoxia. It was manifested in a decrease in systolic and developed pressure and disturbances in diastolic relaxation of the myocardium. Damage to cell membranes and increased secretion of aspartate transaminase into the coronary circulation were observed under conditions of energy deficit and activation of the anaerobic pathway of energy production. These changes became more pronounced with increasing the period of hypoxic exposure.
The interaction of genetic and environmental factors leads to development of autoimmune diseases. Autoimmune diseases have common pathogenetic mechanisms and are combined often. in recent years Epidemiological studies have shown a significant increase in the prevalence of celiac disease in patients with type 1 diabetes mellitus (T1DM) in recent years. Comorbid pathology is a heavy clinical case to determine the treatment of patients. The association of celiac disease and T1DM leads to enhanced immune response and rapid development and progression of complications. A gluten-free diet is only treatment for celiac disease. Gluten-free diet complicates glycemic control. This article presents our clinical case of a patient with combination of celiac disease and T1DM.
Investigation of pathogenetic correlation of abdominal adisposity and II-type pancreatic diabetes (PD) has been made with the aim to reveal the importance of carbohydrate metabolism disturbances at above said pathology combination in cardiac abnormalities. 30 white alley rats at the age of 8-12 months have been included into the experimental group. Control group has been formed of 30 animals. Used methods of investigation: simulation of II-type PD in rats with streptozotocin and study of carbohydrate metabolism indices in entire organism as well as contractile function indices and indices of isolated and contracting heart metabolism. As a result it has been revealed that the weight of rats with II-type PD and abdominal adisposity, the level of glucose and glycated haemoglobin in blood, of lactate and pyruvate had been increased surely. The normal level of blood serum C-peptide has confirmed the absence of mass death of β-cells. The hearts taken from diabetic animals have responded to the increase of contraction frequency with the decrease of advanced pressure, i.e. the negative inotropic effect has been observed. Therefore the peripheral insulin resistance plays the leading role in the development of metabolic and functional abnormality complex at II-type PD and abdominal adisposity. Accumulation of lactate, metabolic acidosis, decrease of glucose efficiency and dysfunction of cardiac hystiocyte calcium pump with the development of diastolic myocardium dysfunction contribute to the development of metabolic disturbances.
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