Relevanc. Measles, mumps and rubella, despite many years of vaccination, retain their epidemiological and social significance at the present time. The aim of the work is to study the safety and immunogenicity. Of the vaccine for the prevention of measles, rubella and mumps Vactrivir® in children's immunization. Materials and methods. The safety and immunogenicity of the vaccine was studied in a simple multicenter blind comparative randomized clinical trial involving children aged 12 months and 6 years. Results. The Vactrivir® vaccine is characterized by low reactogenicity, a high safety and immunogenicity profile and is comparable in terms of indicators to the foreign Priorix® vaccine, which has been used in the Russian Federation for specific prevention of measles, rubella and mumps since 2018.

The article presents the results of an open comparative randomized clinical study on the assessment of the reactogenicity, safety and immunogenicity of the domestic vaccine "EntseVir®" with reduced antigenic load in immunization of children aged 3 to 17 years on the schedule for 0-60 days. The vaccine is characterized by the low reactogenicity, high safety profile and immunogenicity. On main indices, it is not inferior to foreign vaccine «FSME-Immun Inject / Junior».

The article presents the results of the open comparative randomized clinical study performed in children aged 3 to 17 years which were immunized with the Russian vaccine «EnceVir»® possessing the reduced antigenic load accordingly to emergency vaccination protocol. The aim of the study was to assess reactogenicity, safety and immunogenicity of the vaccine. The vaccine is characterized by a low reactogenicity profile, the high profile of safety, adequate immunogenicity, and it is not yielding to foreign vaccine «FSME-Immun Inject / Junior»

The paper presents historical stages in the development of the Department of Epidemiology and Hygiene of E.A. Vagner Perm State Medical University. The evolution of technologies, forms and methods used in educational process are described. There are formulated the directions of activity of the department and the experience of work with organs and institutions of public health and Rospotrebnadzor.