Pro-Pro-OMe, and Z-(Gly-Pro-Ala),-OMe (n = 1,2, . , . ,4) were synthesized step-by-step and then studied by means of x-ray diffraction, ir spectroscopy, the kinetics of hydrogendeuterium exchange of peptide groups, and circular dichroism. Different stages in the formation of a triple helix in Z-(Gly-Pro-Pro),-OMe were revealed during the chain elongation. In the solid state, at the first stage a conformation of the polyproline 11-type is formed in the tripeptide and in the second stage a triple-helical complex appears in the hexapeptide. Interpeptide hydrogen bonds in this complex are still of low order. At further stages an ordered set of interpeptide hydrogen bonds is gradually formed. It is shown that the degree of order of interpeptide H bonds depends on the length of the molecular chain, the amino acid composition, and residue sequence in the triplets.

New adamantane derivatives with amino acid residues and other bifunctional compounds were synthesized and their antiviral activity towards influenza A(H1N1)pdm and A(H3N2) viruses was studied. Some of these adamantane derivatives completely suppressed replication of remantadine-resistant influenza A virus strains.

Оценка противовирусной активности соединения 2HCl*H-His-Rim в сравнении с противогриппозным препаратом «Арбидол» в отношении высоковирулентного штамма вируса гриппа A/duck/Novosibirsk/56/05 (H5N1) (Influenza A virus, Alphainfluenzavirus, Orthomyxoviridae) 1 ФГБУ «Национальный исследовательский центр эпидемиологии и микробиологии имени почётного академика Н.Ф. Гамалеи» Минздрава России,

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