With the application of the method of risk assessment, there have been studied effects of chemicals in food on the population health in the Omsk region in the period 1996-2012. The level of contamination of food with chemical carcinogens increased in the periods 1996-2004 and 2009-2012. The population carcinogenic risk was 5 х 10 -4 and 6.6 х 10 -4 respectively (the levels unacceptable for the population on the whole). The risk of noncancer effects was assessed taking into account influence on the critical organs (systems). The value of the hazard index (HI) > 1 (not acceptable) in the period 1996-2004, was received for the effects on the nervous system (central and peripheral), the cardiovascular system and skin; in the period 2009-2012, the critical organs and systems were the endocrine, cardiovascular, central nervous, urinary systems, the gastrointestinal tract, the blood system, the immune system, skin. Generally in the period 1994-2012, the levels of toxicants' effects in food increased, what caused an increased number of the organs (systems) - targets. Due to the content of chemicals, mainly arsenic, the main food groups with adverse effects on the human body were bakery goods and products of grain processing.

Currently, many developed countries have produced and applied population standards of quality of life, which are used as health status indices in formulating preventive measures and assessing their effectiveness. The study of children and adolescents quality of life is important, as it is one of the population health status indices. In this research, the population standards of adolescents quality of life were studied and justified on an example of Omsk region as a large administrative-territorial unit in the Western Siberia. The research was implemented in compliance with the methodology for the study quality of life. The general well-being quality of life questionnaire PedsQL 4.0. was used as the primary tools. We have investigated the quality of life of 427 students of secondary schools aged 13 to 17 years, residing in the city of Omsk and Omsk region. Among the surveyed were 183 boys and 244 girls. The median values and the 25th and 75th percentiles for the individual scales were: physical functioning (FF) to 87.5 (71.9-100.0) points, emotional functioning (EF) - 70.0 (50.0-85.0) points, social functioning (SF) - 95.0 (75.0-100.0) points, school life (SL) - 70.0 (55.0-90.0) points, psychosocial health (PH) - 76.7 (63.3-88.3) points and the total score (TS) was 81.5 (67.4-90.2) points. The peculiarities of formation of indices were studied depending on the gender of the subject, the area of residence and their state of health. The adolescents with a chronic disease in remission and attending the educational institution were determined to have the lower quality of life rates by reducing physical functioning. The relative distribution of quality of life indices for the individual scales of the questionnaire does not depend on the area of residence; there is an evidence of the existence of the formation of quality of life indices regularities and their relations among themselves. The results of the study are characterized by the sensitivity and reproducibility, which allowed designating the obtained values as regional population-based standards of quality of life.

Background. Non-adherence to treatment, especially in chronic conditions, is a significant problem facing clinical medicine. Failure to adhere to treatment recommendations is often noted in the treatment of osteoporosis, which reduces the effectiveness of anti-osteoporotic drugs and a set of measures to prevent the occurrence of osteoporotic fractures.Aim. The aim of the study was to assess the adherence of patients of the Center for the Prevention and Treatment of Osteoporosis to treatment with anti-osteoporotic drugs of pathogenetic action.Materials and methods. This continuous observational study analyzed the adherence to long-term anti-osteoporotic therapy of patients observed at the Center for the Prevention and Treatment of Osteoporosis, the reasons for discontinuing treatment, doctors’ preferences in prescribing anti-osteoporotic therapy, reasons for changing the anti-osteoporotic drug. The study period is from July to December 2019.Results. During the analyzed period, 625 patients turned to the Center for the Prevention and Treatment of Osteoporosis. The preferences of doctors when prescribing anti-osteoporotic therapy have changed: the proportion of prescriptions for zoledronic acid and denosumab increased, mainly due to a reduction in the prescriptions of strontium ranelate, as well as risendronic acid, teriparatide, and calcitonin was no longer prescribed. Among 370 patients who received a therapeutic appointment (with an already known outcome of a therapeutic appointment), 40.0 ± 2.5% were non-compliant. Including: 9.7 ± 1.5% did not start taking the drug, interrupted the course ahead of schedule — 28.7 ± 2.4%. The termination of the course of therapy in 57.7% of cases was unauthorized, in another 42.3% it was associated with side effects. Patients started and continued further therapy with the initially prescribed drug in 53.8% of cases. As expected, the best adherence rates were found for drugs with parenteral administration once a year (zoledronic acid).Conclusions. Comparative analysis of the prescriptions of the main drugs of the pathogenetic action of patients of the center for the prevention and treatment of osteoporosis showed low compliance.

Background. In addition to regulating mineral metabolism and bone metabolism, vitamin D is important for supporting structure and other types of connective tissue. Studies have shown the role of vitamin D deficiency in the pathogenesis of systemic inflammatory diseases of the connective tissue, autoimmune diseases. The results of studying this problem in countries with different geographic locations are also of interest.Aim. Comparative assessment of vitamin D status of patients with systemic inflammatory diseases of the connective tissue and patients without rheumatic diseases.Materials and methods. This cross-sectional observational study analyzed the vitamin D supply of the following groups: patients with systemic inflammatory diseases of the connective tissue who do not take vitamin D preparations, patients with systemic inflammatory diseases of the connective tissue who take vitamin D preparations, and «conditionally healthy» individuals, without complaints, examined in the same period comparable in gender and age with the patients of the main group. The vitamin D supply of the studied patients was determined by the level of the content of the vitamin D metabolite calcidiol in the blood serum 25 (OH) D. Study period: January 2019 to December 2020.Results. The data of 625 patients who applied to the Osteoporosis Prevention and Treatment Center for the specified period were analyzed. Among the patients of the main group who did not take vitamin D preparations, a deficiency was revealed in 54.7% of the examined, the optimal provision in 11.2%. The median serum 25 (OH) D concentration was in the range of 19.0 ng / ml deficiency. The study participants belonging to the comparison group had a deficit in 44.1% of cases and an optimal provision in 21.5%. The study group of the main group receiving vitamin D preparations had the maximum number of individuals with the optimal status – 37.0%, while a significant part of the examined had a deficit of varying severity – 29.1%. In addition, this group was characterized by the highest median serum metabolite 25 (OH) D – 26.0 ng / ml.Conclusion. A comparative analysis of the D-vitamin status of patients with systemic inflammatory diseases of the connective tissue and «conditionally healthy» individuals without complaints was carried out, which made it possible to establish differences in the provision depending on the existing disease, as well as depending on the therapy with vitamin D preparations. a lower supply of vitamin D than control group «healthy» individuals. In the case of receiving vitamin subsidies, the provision with it in the group of patients was statistically significantly higher, both in comparison with patients who did not take the vitamin, and in comparison, with individuals from the comparison group.