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Over the past years there has been a growing interest to vegetable raw materials evaluated from the viewpoint of their potential antimicrobial activity. Vaccinium genus plants are known to contain a whole spectrum of biologically active substances with anti-inflammatory, antidiabetic, gene-protective, antioxidant and antimicrobial properties. The purpose of the work was to study the antimicrobial, antioxidant and some biochemical properties of alcoholic extracts of fruit and leaves of Vaccinium vitis-idaea L., gathered in the Ukrainian Carpathians. Methods. The plants for the study were gathered around the village of Pylypets, Mizhhiria rayon, Zakarpatska oblast (Transcarpathia). From the fruit and leaves, ethyl and methyl extracts were produced. The subjects for study were their antioxidant activity (by DPPH method), total tannin and flavonoids (by spectrophotometric method), and antimicrobial activity (by diffusion-into-agar method). For the purpose of study, type and clinical isolates were used from the oral cavity of human patients suffering from inflammatory diseases of periodontium, characterized by wide resistance spectrum to antibiotics. Results. The reviewed extracts were observed to have a higher antimicrobial activity against Gram-positive bacteria. The highest antimicrobial activity was shown by the extract of Vaccinium vitis-idaea L. fruit. Its antimicrobial activity was registered upon both test and clinical isolates of S.aureus, including methicillin-resistant ones. The ethyl fruit extract and methanol leaf extract were established to show high antimicrobial effect upon S.pyogenes. The ethanol fruit and leaf extracts and methanol fruit extract were observed to show weak antimycotic activity. The extracts were characterized by high antioxidant activity, with the highest effect peculiar for ethyl leaf and fruit extracts, and somewhat lower one for methyl extracts. The ethanol fruit extract was characterized by the highest tannin level out of all extracts under review. Conclusions. The antimicrobial and high antioxidant activity of the ethanol extract of Vaccinium vitis-idaea L. fruit and leaves, and absence of the antimicrobial effect against the probiotic strain of Lactobacillus plantarum, characterized by the antagonistic activity against opportunistic microorganisms, cause the advisability of their complex application as the basis for phytobiotics.

One of the most socially important types of work is the work of medical workers. Due to the presence of a significant number of harmful and dangerous factors, the medical profession is divided into a separate group, which in turn is characterized by unique aspects of work. The work of doctors and nurses of different specialties of the dental profile differs significantly in the density of the working day, the volume and nature of professional activities; responsibility for the life of the patient, which affects many physiological processes. The purpose. Assessment and comparative characterization of the presence of occupational risks in the dental field, which are daily exposed to factors of aggressive and dangerous nature, as well as the development of a set of preventive measures aimed at reducing occupational morbidity. Materials and methods. Hygienic research of working conditions of medical staff of the University Dental Clinic in the form of a questionnaire. Statistical analysis of data of special assessment of working conditions; sanitary and hygienic characteristics, acts, maps of cases of nosocomial diseases; laboratory and instrumental research conducted as part of production control; dosimetric control, air sampling with subsequent sowing on the nutrient medium of IPA. Results. It was found that in the studied premises, the total microbial count varied from 756 ± 0.8 CFU / 1m3 to 6497 ± 3.4 CFU / 1m3. In most medical institutions, the level of artificial lighting in the workplaces of medical workers was insufficient. The largest negative contribution was provided by such production factors as: labor intensity and intensity - 26.41%; physical: noise, vibration, non-ionizing and ionizing radiation - 25.32%; chemical - 12.77%. The total contribution of the main factors was 91.78%. Assessment of working conditions is based on hygienic criteria to assess the degree of deviations of the parameters of the production environment and labor process from the current hygienic standards, as well as after analysis and processing of data submitted by employees in the format of their questionnaires. In this regard, the distribution of harmful production factors and their degree of impact on the health of medical personnel was established with the help of multifactor analysis. Conclusions. Thus, the research interprets the results, which clearly in the format of a specific percentage, identify those factors that have a strong driving impact on the health of dental professionals. The most substantiated are such production factors as: chemical (exposure to drugs and chemicals), physical (noise and vibration, non-ionizing and ionizing radiation), the severity and intensity of the labor process, lighting (non-compliance with regulations for artificial lighting in the workplace) and microclimate and biological (work with biological, potentially contaminated material, samples, patients), non-ionizing and ionizing radiation, labor intensity (tension of the visual organs).