The article provides the evaluation results of the body functional state of mining production workers associated with the extraction and processing of loparite ore. The complex influence of the work conditions on appearance of autonomic dysfunction in the regulation of heart rate variability (HRV) was revealed in workers employed in the ore mining and processing. This dysfunction manifests in the stress indices increasing, earlier exhaustion of the adaptive reserves in comparison to the experimental group, decrease of the total autonomic nerve system effect on heart rate and the increase of the sympathetic nerve system impact to the HRV regulation. High contribution of the very low-frequency component to the spectral range of HRV of the surveyed shows the hyper adaptive state of the mining production workers. The failure of adaptation and a high degree of vulnerability to the environmental factors are the next stage of the body state. It was shown that the functional state of the body of underground miners (in the group of persons under 45 years of age) differed from functional state of ground workers. Furthermore the systolic and diastolic pressure were higher in a group of persons over 45 years old associated with underground work and work with high personal responsibility for production than in the group of persons working in the ground conditions. The obtained results showed that certain values of the HRV in miners group aged