СОБСТВЕННЫЕ ИССЛЕДОВАНИЯ • OWN RESEARCHЖурнал «Злокачественные опухоли» • №4 -2015 г. (15) • www.malignanttumours.org Около 70% случаев рака молочной железы (РМЖ) представляют собой гормон-чувствительные опухоли, и основным методом лечения таких опухолей является антиэстрогеновая терапия. На данный момент времени, существенной проблемой остается развитие эндокринной резистентности при применении гормонального лечения. В статье приведен обзор литературы о сигнальных путях, регулирующих опухолевый рост, механизмах развития эндокринной резистентности и о возможных путях ее преодоления. SummaryAbout 70% of cases of breast cancer (BC) are hormone-dependent tumors and the main method of treatment of such patients is antiestrogen therapy. At this time, development of endocrine resistance during this type of treatment remains a significant problem. This article reviews literature on signal pathways that regulate tumor growth, mechanisms of development of endocrine resistance and possible ways to overcome it. 53Механизмы развития и пути преодоления эндокринной резистентности при раке молочной железы Mechanisms of development and the ways to overcome endocrine resistance in breast cancer
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