Проведение клинико-лабораторных исследований позволило у 64 из 158 (40,5%) пациентов с псориазом установить наличие суставного синдрома с определенной клинической симптоматикой, интенсивность которой была оценена по индексу CASPAR. Особенности клинических проявлений псориатического артрита и данные по экспрессии провоспалительных цитокинов (TNF-α и IL-17) явились основанием для применения генно-инженерных биологических препаратов, в частности секукинумаба, являющегося блокатором IL-17. На курс лечения псориатического артрита понадобилось провести в среднем 10–12 инъекций секукинумаба (доза инъекции препарата составляла 300 мг). Отмечена целесообразность и эффективность применения секукинумаба именно при раннем псориатическом артрите, предупреждающего развитие в дальнейшем инвалидизирующих форм заболевания. Clinical and laboratory investigation made it possible to establish the of joint syndrome with special clinical symptomatology in 64 of 158 (40.5%) patients with psoriasis, the intensity of which was estimated according to CASPAR index. The features of clinical manifestations of psoriatic arthritis and data on the expression of proinflammatory cytokines (TNF-α and IL-17) were the grounds for using genetically engineered biological drugs, in particular secukinumab, which is an IL-17-blocker. An average of 10–12 injections of secukinumab (an injection dose of the drug was 300 mg) were needed for a course of treatment of psoriatic arthritis. The appropriateness and effectiveness of secukinumab use in early psoriatic arthritis was noted, preventing the development of further disabling forms of the disease.
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