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Purpose of the Study: Assessment of the influence of the type of the adapted infant milk formula in infants on the formation of the body resistance. Children Characteristics and Study Methods. 105 virtually healthy children were examined, as follows: 35 children were breastfed (control group), 70 children were formula fed including 35 children that received NENNY with prebiotics formula based on the goat milk (main group), 35 children – formulas based on the cow milk with probiotics and prebiotics (comparison group). The incidence rate of the acute respiratory diseases (ARD) as well as the number of the pneumonia histories in the infants were assessed, and the body resistance index was calculated. The laboratory assessment of the child body immunoresistance was carried out using the method of imprint smears from the nasal mucous membranes and the method of nasal washes. Results. It was determined that there were 2 times more children of the main group with no history of the acute respiratory diseases when infant than in the comparison group. In general, the good resistance (were sick 0-3 times a year) in the main group was registered in 82.9% of the children, while it was only 60% in the comparison group. The average number of the ARD cases per year was 2.3 ± 0.02 in the main group, which is 1.5 times less than in the comparison group – 3.6 ± 0.04 (p <0.05), and in 1, 3 times more than that in the control group – 1.8 + 0.03 (p<0.05). In average, the resistance index was 0.28 ± 0.02 in the main group, while it was 0.36 ± 0.03 in the comparison group, and 0.25 ± 0.02 in the control group. When studying the incidence rate of the community-acquired pneumonia in the infants, it was revealed that 2.8% of them were ill in the control group, 5.7% of them in the main group, and 8.5% in the comparison group. When feeding the child with formulas based on the goat’s milk, the level of mucosal immunity of the nasal mucosa and enzyme systems of the intraleukocyte microbicidal system is assured, which is virtually indistinguishable from the level of immunity achieved with breastfeeding. Conclusion. Adapted NENNY with prebiotics formulas can be recommended for children who are formula fed when infant in order to increase the body’s resistance and to reduce the incidence rate of the acute respiratory diseases and community-acquired pneumonia.

Introduction. Despite new diagnostic methods contributing to an understanding of the etiopathogenesis of acute respiratory tract diseases and a variety of drugs for effective therapy, respiratory tract diseases continue to stand first in the overall morbidity profile in both children and adults. Frequently ill children are most susceptible to diseases, especially at the age of 3 to 6 years old, which accounts for up to 75% of all acute respiratory infection cases and shows no positive response to the medical-preventive activities. The article discusses the relationship between allergic rhinitis and recurrent respiratory diseases.Materials and methods. The possibility and effectiveness of complex treatment of allergic rhinitis in 65 frequently ill children aged 3 to 12 years are considered. The main group consisted of 35 children who were included in the traditional anti-allergic therapy with an isotonic solution of sea salt in an age-related dose for 10 days. The comparison group consisted of 30 children who received only traditional anti-allergic therapy, which was comparable in the compared groups. Patients underwent in-depth clinical and specific allergological examinations, as well as assessment of atopic response parameters of mucosal immunity, including determination of eosinophil levels, side, and Il-4 concentrations in nasal secretions.Results. Thus, the 12-month follow-up control over children with AR showed that the annual frequency of ARIs in the treatment group decreased by 1.4 times and, when averaged, was 5.2 cases, while in the comparison group it was 7.3 cases p < 0.05.Conclusions. In children with recurrent respiratory diseases, suffering from allergic rhinitis, the complex anti-allergic therapy, with the inclusion of elimination and irrigation therapy with a preparation based on isotonic sea salt solution, led to a decrease activity of markers of allergic inflammation in the nasal mucosa, which is confirmed by a decrease in the level of eosinophils, secretory IgE and IL-4 in nasal secretions against the background of a decrease in the frequency of acute respiratory diseases during follow-up for a year.

Introduction. Traditional antiallergic therapy for atopic dermatitis, including allergen elimination, therapeutic cosmetic skin care, external anti-inflammatory therapy and antihistamines, does not always lead to the desired result. On this basis, the search for new methods of treatment is urgent and promisingAim. To study the clinical efficacy of a combination of Lactobacillus rhamnosus GG and prebiotics in children in the first years of life with atopic dermatitis (AD).Materials and methods. The observed children were divided into 2 parts: 30 children aged from 1 month to 3 years old, patients with AD constituted the main group, it differed in that these patients were synbiotic (combination of Lactobacillus rhamnosus GG and prebiotics) – 1 sachet per day for 14 days. This drug was prescribed as part of complex therapy. The remaining 25 children with AD made up a comparison group, which was characterized by the fact that children received only antiallergic therapy without symbiotic. Clinical methods of blood pressure examination, laboratory instrumental and specific allergological methods were carried out.Results and discussion. Against the background of the therapy in children with blood pressure in the main group, общий overall treatment effect was higher and amounted to 86.6 + 4.0%, and in the comparison group – 76.0 + 3.9%, p < 0.05. This was manifested in a decrease in the duration of the exacerbation period by 1.4 times, the prevalence of a high individual therapeutic effect by 1.5 times, a decrease in the SCORAD index by 4 times against the background of an increase in the number of bifidobacteria and lactobacilli in the intestine. The revealed clinical efficacy was noted against the background of an increase in the number of bifidobacteria and lactobacilli in the intestine.Conclusions. The obtained results allow us to recommend a combination of Lactobacillus rhamnosus GG and prebiotics in children in the first years of life as part of complex therapy to increase the effectiveness of treatment.

Intestinal colic, food allergies are one of the common causes of the initial treatment of children in their first year of life in outpatient practice. Gastrointestinal allergy is a lesion of the gastrointestinal tract of an allergic nature, is in second place among the pathologies associated with food allergies, where allergy to cow’s milk proteins leads. In recent years, the diagnosis of lactase deficiency, unreasonably leads to an unreasonable transfer of the child to artificial curing and the appointment of lactose-free mixtures. In some patients with gastrointestinal manifestations, secondary LN is quite often formed. The article discusses the clinical forms of LN and GA. Undigested lactose increases the cell-mediated pro-inflammatory processes in the body, which, in turn, leads to the stimulation of the development of inflammatory and allergic processes in children. The possibilities and effectiveness of concomitant diet therapy are discussed, including using replacement therapy with the enzyme lactase, which eliminates the main cause of childhood colic, helps the absorption of breast milk or mixture, thus providing babies with the necessary nutrients for physiological development. The article presents results of the clinical observation carried out in a group of 20 full term babies aged 2–5 months with secondary lactase deficiency in the setting of gastrointestinal allergy with positive clinical response: highly quick control of symptoms of intestinal dyspepsia, improvement in stool frequency and consistency were detected on Day 7 from the start of enzyme therapy in 85% of children. Symptoms of intestinal colic (95%), flatulence (80%) were also reversed, regurgitation decreased in frequency and volume (85%) by the end of Week 1 of the therapy and completely disappeared by the end of Week 2. Lab tests confirmed the clinical efficacy of the therapy. A significant improvement in coprogram indicators was identified in 80% of children by the end of Week 2 from the start of therapy. The researchers found out that the carbohydrate content in the coprogram decreased by 1.8 times from 1.3% ± 0.5 to 0.7% ± 0.5 (p <0.05) in most children, and there was no significant decrease of this indicator in 20% of patients. The results show that the prescription of enzyme replacement therapy in combined gastrointestinal allergy and secondary lactase deficiency in children aged 6 months helped keep breastfeeding volumes, and reverse symptoms of lactase deficiency in most cases.