The Seebeck coefficient S and the electrical conductivity σ of solid solutions based on bismuth telluride with substitutions in Bi and Te sublattices were studied at pressures up to 12 GPa at room temperature. It is shown that with increasing pressure, the electrical conductivity increases and, despite the decrease in the Seebeck coefficient, an increase in the power factor (S^2)σ is observed in p-Bi0.5Sb1.5Te3 and n-Bi2Te1.65Se0.65S0.7 solid solutions. The maximum increase in the power factor was found for n-Bi2Te1.65Se0.65S0.7 in the pressure range of 3−4 GPa, corresponding to the electronic topological phase transition. The investigated solid solutions were used in the model of a thermoelectric module with adjustable mechanical stress applied to thermoelements.