Introduction: Inflammatory periodontal diseases take one of the first places among dental diseases; they are prevalent in various age groups and tend to grow steadily. The highest morbidity rate is found at the age from 15 to 44, that is 64-98% of the population. For the rational pathogenetic therapy, multiagent medications affecting different parts of the pathological process in a multiple way should be developed. Materials and Methods: In the work, marketing and economic research methods are used to ground social and medical practicability of developing new dental products for local treatment. Results and Discussions: With reference to the analysis of the Ukrainian market, it was found out that a dominant position in the range of dental gels, presented at the national pharmaceutical market is held by imported preparations. Methodological approaches to developing semisolid dosage form for treating inflammatory periodontal and oral mucosa diseases were summarized. Conclusions: Methodological approaches to developing medicine in gel dosage form for treating inflammatory periodontal and oral mucosa diseases were developed. With reference to the proposed methodology for developing gel for applying in dental practice, we theoretically and experimentally grounded the structure and rational technology of new combination preparations "Aloe-Dental" and "Dentatrigin" in the form of gels.

Introduction: Nowadays, biopolymers and biomaterials are an actively developing field, interesting both for specialists from various fields of science and for society at large. The range of polymers of both natural and synthetic origin is constantly expanding, but only a few of them are used in pharmaceutical production and medical practice. Due to the composition of polymers and active pharmaceutical ingredient, films are a promising form for applying in dentistry, ophthalmology, surgery, and other fields of medicine. Materials and Methods: In the work marketing and economic research methods are used to ground social and medical practicability of developing new dental products for local treatment. Results and Discussions: Based on the data of modern scientific literature, the requirements for medicinal films are outlined, their classification is given. Approaches to the choice of active and auxiliary substances in the process of developing new film formulations are described. The prospects of using films in surgery, dentistry, ophthalmology, and dermatology are shown. Conclusions: Based on the review, polymer films have been classified, and the requirements for the given dosage form have been defined. Approaches to selecting active and auxiliary ingredients have been considered. The main aspects of the technological process for the preparation of films are described. The ways of rational application of films in medical practice have been highlighted.

Aim. To theoretically substantiate the composition of a wound healing ointment with active substances of plant origin for the therapy in the second and third phases of the wound process. Materials and methods. The study object was the generalization and analysis of scientific literature data on the use of medicinal plants in the treatment of the wound process. Results and discussion. Based on the analysis of scientific literature data on the chemical composition and pharmacological properties of medicinal plants used in the treatment of the wound process, the expediency of using the lipophilic extract of marigold flowers, amaranth oil, fennel essential oil as active ingredients in the wound healing ointment has been substantiated. Marigold flowers due to the presence of a large number of carotenoids and flavonoidswill provide a high level of the antimicrobial, reparative action of the ointment. Due to the content of complex biologically active compounds, such as tocopherols, polyunsaturated fatty acids, vitamins, phytosterols and squalene, the amaranth oil has a pronounced antioxidant activity. The components that are part of the essential oil of fennel contributeto the connective tissue growth and the skin restoration, as well as provide a high level of the antifungal action. Conclusions. The analysis of scientific literature data has shown the possibility of using herbal medicines in the treatment of the wound process. The greatest advantage of herbal medicines is the high degree of assimilation of molecules of biologically active substances, which are part of natural compounds as the most physiological form, by skin cells. The expediency of using the lipophilic extract of marigold, amaranth oil and fennel essential oil when developing a wound-healing ointment has been proven. The composition selected will provide the predicted antibacterial, antifungal, antioxidant and reparative effect of the ointment, reduce the likelihood of resistance in pathogenic microorganisms, and accelerate granulation and epithelialization of tissues.

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The results of modern research on the creation of pharmacologically active bandage were generalized. The main components of the development of pharmacologically active dressing (choice of active ingredients, carrier substrate, the method of immobilization, etc.) were determined. Methodological approaches to the creation of pharmacologically active bandage were developed. The practical significance of the developed methodological approaches was demonstrated by research and development of dressings with thick oak bark extract.