Background: Current statistics show that the highest incidence of genital herpes is observed among women of reproductive age. Since these patients have an active lifestyle, frequent outbreaks of genital herpes can cause physical and psychological discomfort. Aim. To assess the quality of life of women of reproductive age with recurrent genital herpes. Methods: The quality of life in women suffering from recurrent genital herpes for more than 5 years (n=86) was evaluated. The control group included healthy women (n=91) according to the data of external genitalia examination and PCR diagnostics. The Health Status Survey (SF-36) in points was employed to measure the health status of women in both groups. Results: We established a significant difference between two groups of patients in terms of the influence of the following indicators on functional limitations: general health condition — 12.1±0.8 points; pain — 8.3±0.4 points; physical problems — 18,3±3,7; physical activity — 8.2±0.6 points (p<0.01). Conclusion: Symptoms of herpetic infection and longterm persistence have an impact on the performance of daily tasks and the quality of life of the patient.