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Purpose of the study: to prove the pathological effect of chronic viral hepatitis on sexual development (SD) and menstrual function of adolescent girls by analyzing the secondary sexual characteristics and to determine the features of disorders of menstrual function (DMF)  in such patients.Materials and methods. The study involved 150 girls of pubertal age (12–17 years) who were divided into groups: the main group (n = 50) – patients with DMF and SD on the basis of chronic viral hepatitis B and C; comparison group (n = 50) – patients with DMF and SD on the basis of hepatobiliary system diseases (cholecystitis, dyskinesia of the biliary tract); control group (n = 50) – almost healthy girls. All patients underwent clinical analysis of menstrual function, appearance and development of secondary sexual characteristics, clinically determined the degree of SD and SD score calculated.Results. The whole spectrum of DMF in the main and comparison group was revealed. There were more patients with hypomenstrual type of DMF in the main group than in the comparison group: 37 (74%) against 28 (56%) (p <0.05). Patients with juvenile uterine bleedings were almost equally: 8 (16%) in the main and 7 (14%) in the comparison group (p <0.05). There were three times more patients with dysmenorrhea in the comparison group – 15 (30%) girls against 5 (10%) in the main group (p <0.05). The dependence of SD disorders and clinical form of DMF on the time of hepatitis development in the main group was revealed: SD delay and primary amenorrhea were more often with the disease onset in childhood, persistent oligomenorrhea was formed in the prepubertal period, and juvenile uterine bleedings and secondary amenorrhea in the late puberty (p <0.05).Conclusions. This study demonstrated the role of hepatobiliary system diseases in slowing puberty of girls, characterized by disturbance of the secondary sexual characteristics onset, deviation of the SD score. Dependence of DMF on periods of exacerbation of hepatobiliary system diseases was also determined.

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Reproductive health is a reflection of health during childhood, and crucial during adolescence and adulthood, sets the stage for health beyond the reproductive years for women and affects the health of the next generation. Many different types of educational programs, based on local peculiarities have been shown to positively affect reproductive health outcomes. Thus we decided to analyze the "Questionnaire adolescents 15-18 years" of 532 girls from the database of Ukrainian longitudinal study "Family and Children of Ukraine" using parameters that characterize main social factors of influence on formation of life style habits at adolescent girls.Among the surveyed adolescent girls fairly high amount does not demonstrate a high level of awareness in the issues of reproductive health, sexual development and sexual relationships. Evident link between the level of communication with adolescents and parents and level of knowledge on reproductive health issues at this group of girls was found -the girls that point on the family communication deficits had given less informative answer on questions concerning the development of the reproductive and sexual relations, and more often choose as information source on this topic unreliable and badly controlled sources -friends, the media and the Internet. However, among adolescents who are satisfied with the level of communication with their parents (vast majority -97%), the percentage of badly informed is also noticeable.Parameters that are considered as risk factors for social anamnesis -property status, education level of parents, family housing -don't have a real impact on the deficit in family communication and adolescent's awareness. However, it is worth noting that 56% of girls didn't receive information about reproductive and sexual development from specialists -health workers, psychologists and teachers, but their level of knowledge doesn't significantly differs from those who got such information from experts.We can conclude that existing educational programs are not sufficiently effective, and the means provided for existing programs do not provide adequate coverage of adolescents.