Objective: The aim of the study was to study the effect of antenatal ethanol intoxication on the postnatal development of the heart muscle during the neonatal period. Materials and methods: The experiment was carried out on 24 pregnant female rats weighing 180-200 grams. The animals were divided into 2 groups: experimental and control. 12 animals of the experimental group were injected with a 30% ethanol solution from 6 to 21 days of gestation daily, once, endogastrically, at a dose of 5 g / kg. The animals of the control group were injected with the same volume of physiological saline. Results and Discussion: On the 1st and 7th days after birth, the rat pups were killed by decapitation under light ether anesthesia. After determining the mass of the heart, part of the organ was studied electron microscopically, part was fixed in 10% neutral formalin, then histological preparations were prepared in accordance with standard methods. Sections were stained with hematoxylin and eosin. The nuclear-cytoplasmic ratio in cardiomyocytes, the specific density of the capillary network of the myocardium, and the specific density of cardiomyocytes were measured. The data obtained were statistically processed. Conclusion: The study showed that antenatal ethanol intoxication has a pronounced effect on the postnatal development of the heart muscle during the neonatal period, which manifests itself at the cellular and subcellular levels. The value of the obtained results lies in the fact that for the first time ultrastructural changes in postnatal development in the neonatal period of the fetal heart muscle during prenatal ethanol intoxication are shown at the electron microscopic level. Bangladesh Journal of Medical Science Vol. 21 No. 02 April’22 Page : 344-353

Objective. The purpose of thisstudy was to determine the chronic toxicity of the drug “Harmine hydrochloride, capsules” for preclinical evaluation of its safety. Materials and methods.The experiment was performed on 48 CD-1 rats. Harmine hydrochloride was injectedto the animals intragastrically at doses of 2.5 mg / kg/per day, 5 mg / kg/per day, 9 mg / kg/per day, 10 mg / kg/per day for 3 months. After 3 months, the animals were withdrew from the experiment, internal organs (brain, heart, spleen, adrenals) were weighed and set in 10% neutral formalin. Histological specimenswere mounted in accordance with standard procedures. Results and Discussion. All morphological, histopathological changes, in addition to mortality and bodyweight changes were recorded.Microtome cuts, 5 micrometers thick, were stained with hematoxylin and eosin. Conclusion. As a result of the morphological study, there was no toxic effect of harmine hydrochloride at doses of 2.5 mg / kg, 5 mg / kg, 9 mg / kg and 10 mg / kg on the brain, at doses of 2.5 mg / kg and 5 mg / kg on the structure of the heart, spleen and adrenal glands. At doses of 9 mg / kg and 10 mg / kg, there is an initial toxic dose-dependent effect on the heart, spleen and adrenal glands. Bangladesh Journal of Medical Science Vol.18(3) 2019 p.598-606

The article's abstract is no available.