In recent years сytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) became popular in pediatric oncologic surgery. This procedure is a “treatment of choice” for determined groups of adult patients. The approaches for preoperative diagnostics and surgical technique are well described in adult patients, but not for pediatric surgery, considering limited experience in сytoreductive surgery and HIPEC in children. This review summarizes literature datas of tumor dissemination, diagnostics and technical features in peritonectomy based on tumor localization and analysis of possibility to use these techniques in pediatric patients.
Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign tumor that affects almost exclusively male adolescents. Usually, symptoms of JNA are detected within 15–24 months before seeking medical help. JNA is mainly diagnosed in patients aged 14 to 25 years. Angiofibroma consists of a complex mixture of blood vessels and a fibrous stroma. This feature of their structure determines the property of the tumor to bleed massively even after minimal surgical procedures. The tumor usually grows posteriorly and upward, involving the sphenoid sinus. Under certain circumstances, it can spread anteriorly into the nasal cavity with the involvement of ethmoid cells. With lateral spread, it affects the space of the pterygo-palatine fossa and can also spread into the infratemporal fossa through the expanded pterygo-maxillary fissure, into the region of the chewing muscles and soft tissues of the cheek. In this review, we briefly outline the study history, and current aspects of etiology, pathogenesis, diagnostic and treatment methods of JNA.
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