Introduction. Low back pain (LBP) is a global health problem and it concerns approximately 80% of population of the definite age period. Physical therapy (PT) has a systemic effect on the body and it is one of the main methods of increasing the level of non-specific resistance, correction of locomotor disorders. The influence of PT on the formation of persistent remission has not been studied enough. Aim: is to evaluate the anti-relapse effect of physical therapy methods in patients with LBP. Comparative Study. Methods. In the study, 2 groups were formed, the main group (52 people), whose patients, along with non-steroidal anti-inflammatory drugs (NSAIDs), muscle relaxants, and physiotherapy, received individual courses of physical therapy, including independent classes. In the control group (49 people), patients who refused physical therapy and other types of additional physical activity received only medication and physiotherapy. The study of the effectiveness of therapy included neuroorthopedic examination with the calculation of the integral indicator (II) in points. Results. The groups were comparable by gender, age, and clinical manifestations of the disease. In statistical analysis, the subjective assessment of wellbeing, at the initial level, after 3 months and 12 months-at the end of treatment, which did not differ in the groups at the beginning of the study, became significantly higher in the main group (p 0.000001) during follow-up for a year. The subjective assessment of pain by visual-analog scale (VAS) also significantly decreased (p 0.000001). The integral indicator of biomechanical disorders was significantly lower at the end of the course of treatment, as well as during the catamnestic study in the main group (p 0.000001). Conclusion. The study showed a high significance of exercise therapy in the complex of rehabilitation measures aimed at preventing LBP, modulating both subjective well-being and the course of the pathological process, extending the period of remission and correcting pain and biomechanical manifestations.