Disorders in the fetoplacental complex of pregnant women with chronic respiratory diseases (CRD) is one of the actual problems of modern obstetrics in medical, economic and social aspects. Respiratory diseases in the context of disorders of the fetoplacental complex (FPC) may be a comorbid process, a background to the pathology of pregnancy, or a premorbid condition that contributes to the development of placental dysfunction (PD) or even initiates it; morphophysiological changes characteristic of pregnancy also affect the state of the respiratory system, moderating the course of bronchoobstructive pathology. The presence of respiratory diseases in women, the impact of its treatment and features of the course and medical support of pregnancy in these conditions affect the condition of both the woman and the fetus, and in the future - the physical and neuropsychological development of the child.

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Diabetes mellitus is a common chronic disease in the women of reproductive age. Pregnant women with this disease often have placental dysfunction, which manifests itself in fetal growth retardation, dehydration and requires delivery by a cesarean section. To evaluate the effect of antiprogesterone use on cervical maturation and optimization of delivery in pregnant women with placental dysfunction resulted from diabetes, 120 women were examined according to generally accepted norms. Ultrasound examination with Doppler velocimetry of the fetoplacental complex vessels and measurement of the uterus neck, hormonal examination to determine the level of hormones (progesterone, oxytocin, prostaglandin E2) by enzyme−linked immunosorbent assay, endothelial dysfunction factors (VEGF, endothelin, еNOS), assessment of uterus neck according to Bishops' score and the course of childbirth by cardiotocography and partogram, the newborn condition on the Apgar scores, newborn weight, glycometric condition of the mother. Preparation of pregnant women for childbirth was carried out by intracervical injection of prostaglandins of group E2 (dinoprostone); Foley catheter; antiprogesterone drug (mifepristone). The research has found that diabetes complicates the course of pregnancy with placental dysfunction in almost every second pregnant woman due to endothelial dysfunction, especially in the fetoplacental complex, which can be determined at an earlier stage of pregnancy by studying endothelial factors. The need for initiating the premature birth in pregnant women with diabetes is stipulated by the impairments in mother and fetus (placental dysfunction, diabetic fetopathy, distress), which requires preparation of the cervix for the labor induction. The most effective pre−induction of pregnant women with diabetes was the pathogenetic method of intracervical administration of antiprogesterone, which did not have a negative effect on the body of mother and child. Key words: diabetes mellitus, placental dysfunction, pregnant women, antiprogesterone.

Genital prolapse (GP) is one of the leading gynecological diseases and is diagnosed in 30–50% of women, especially the elder ones. Its related disorders lead to social, psychological and clinical disorders in the form of social isolation, depression, sexual dysfunction, etc.Purpose of the study was to optimize the prevention of GP recurrence in elderly women after surgery.Materials and methods. 56 women aged from 60 to 82 with GP of III–IV degree of severity were examined and divided into 2 groups depending on the treatment method and prevention. 26 women in the first group were prescribed vaginal suppositories Revitaxа for 30 days after surgical treatment to increase the GP recurrence prevention. 30 women in the second group underwent traditional surgical treatment of GP without additional local therapy. Surgical treatment of women with GP included transvaginal extirpation of uterus without appendages, anterior colporrhaphy, colpoperineoraphy with levatoroplasty, sacrospinal colpopexy in 39 (69.6%) patients and anterior colporrhaphy, colpoperineoraphy with levatoperoplasty in 17 patients. Operation was supplemented by laparoscopic intervention due to the need to ovary remove in 2 women.Results. The proposed method of GP recurrence prevention in elderly women (unilateral sacrospinal fixation of the vaginal dome during surgical treatment of GP III–IV degrees which was followed by using vaginal suppositories Revitaxа for 30 days) allowed obtaining a 100% result in contrast to 90% in women with surgical treatment of GP without Revitaxа.Conclusion. The unilateral sacrospinal fixation of the vaginal dome during surgical treatment of GP III–IV degrees and using vaginal suppositories Revitaxа for 30 days after surgery is recommended to prevent the recurrence of GP in elderly women