Background. The prevalence of congenital malformations of the vessels or angiodysplasia ranges from 1:50,000 to 1:5,000,000. Congenital angiodysplasia is a consequence of impaired formation and development of the vascular system in embryogenesis. The aetiology of angiodysplasia remains poorly studied, and the diagnosis involves significant difficulties in some cases. Clinical Case Description. The observation of a rare case of a combined malformation of vessels and thymic aplasia in a female infant is presented. Angiodysplasia included the syndrome of congenital generalised phlebectasia (synonym: congenital telangiectatic marbled skin) combined with multiple vascular malformations with predominant vascular lesions of the brain, lungs, heart, kidneys, and mesentery. Clinically, the disease was characterised by a generalised change in the skin in the form of livedo reticularis accompanied by the development of severe pneumonia, persistent urinary syndrome, neurological symptoms (convulsive seizures, motor disorders), and progressive heart failure. The diagnosis was confirmed in the course of a pathological study. Conclusion. The presented case allows expanding the notion of the variety of clinical manifestations of congenital angiodysplasia, as well as its possible combinations with other malformations.

Introduction. The research carried out confirms the great importance of zinc in the processes of children'sgrowth and development. Aim. To investigate the zinc content in blood serum of children with short stature. Methods. We examined 42 children under supervision in the children's endocrinology department of the Chernivtsi Oblast Children's Hospital during 2011-2018, aged 3 to 15 years. The control group consisted of 44 children aged 3-15 years. Determined the level of growth hormone (GR), IGF-1 and zinc in the blood plasma. Results. It has been detected that the level of zinc in blood plasma is reducedin 90, 4% of children with short stature. On average, zinc level in the blood plasma of children with short stature was 0.71 ± 0.03 μg/ml, which is significantly lower (p˂0.001) than the mean zinc level in children in the control group -1.11 ± 0.02 μg/ml . In all age groups, there was a significant decrease in zinc values in plasma compared to those in the corresponding age group of the control group. In 28 (cases the level of zinc was quite low, in 10 cases it was very low and in the rest of the cases it had boundary indices. Indices of zinc in blood plasma in children with somatotropic insufficiency were the lowest and averaged 0.66 ± 0.03 μg/l, p˂0.05. Age and gender dependency of zinc level in blood plasma was not found. Conclusions. Zinc deficiency in plasma is observed in most children with short stature. Necessary for zinc deficiency correction in patients with short stature by diet expansion incorporating food enriched with the microelement or the designation of appropriate zinc preparations. Diet expansion may be the subject of further research.

Под наблюдением находился 31 ребенок в возрасте от 6 месяцев до 6 лет с внебольничной пневмонией, получавшие в качестве этиотропной терапии азитромицин. Из них 20 детей получали Азитрокс суспензию, 11 детей-Сумамед суспензию (группа сравнения). Результаты исследования показали, что по эффективности и безопасности применения препарат Азитрокс суспензия для лечения внебольничных пневмоний у детей сопоставим с оригинальным препаратом Сумамед суспензия, что характеризует его как качественный генерик отечественного производства и позволяет рекомендовать для широкого использования в педиатрической практике.