No abstract

The effect peptides KE, KED, AED and AEDG on proliferation (Ki-67), regeneration and aging (CD98hc), apoptosis (caspase-3), and extracellular matrix remodeling (MMP-9) in skin fibroblasts during their aging in culture were studied by immunofluorescent confocal microscopy. All studied peptides inhibited MMP-9 synthesis that increases during aging of skin fibroblasts and enhanced the expression of Ki-67 and CD98hc that are less intensively synthesized during cell aging. Peptides AED and AEDG suppressed caspase-dependent apoptosis that increases during aging of cell cultures.

For the present time the problem ofprevention and treatment of infections associated with the delivery of health care (IAHC) in surgical departments remains to be the one of the most important worldwide. IAHC aggravate the general state ofpatients and increase the duration of hospital stay. Aim: to perform the analysis of IAHC in surgical departments with bearing in mind their nosological forms and etiological features. At the base of the analysis there was taken an analysis of4504 cases of IAHC, recorded in surgical departments in Chelyabinsk for 9 years. In the structure of IAHC the prevalent place was occupied by infections in the area of surgical interventions and respiratory tract infections - 44.5% and 43.3%, respectively. There was noted the change in the structure of IAHC: the number of recorded infections in surgery tends to decrease (from 66.4% in 2004 to 31.1% in 2012), while the number of recorded bloodstream infections and urinary tract infections is increasing annually (from 0 in 2004 to 8.6% and 7.0% respectively in 2012). In the etiological interpretation of IAHC the plenty large enough part (from 5.8% of infections of the urinary system and 19.7% of infections in the surgical intervention) remains to be unexplained, that indicates to the defects of the samplings of the biological material and precludes to perform the adequate etiotropic therapy. There was shown the needfor the realization of the differentiated approach to the development of the measuresfor the prevention of IAHC.